Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466395994> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2466395994 endingPage "551" @default.
- W2466395994 startingPage "547" @default.
- W2466395994 abstract "Prenatal maternal stress can be transferred to the fetus via a catecholamine-dependent decrease of uterine blood flow (UBF). However, it is unclear which group of adrenergic receptors mediates this mechanism of maternal-fetal stress transfer. We hypothesized that in sheep, alpha 1-adrenergic receptors may play a key role in catecholamine mediated UBF decrease, as these receptors are mainly involved in peripheral vasoconstriction and are present in significant number in the uterine vasculature. After chronic instrumentation at 125 ± 1 days of gestation (dGA; term 150 dGA), nine pregnant sheep were exposed at 130 ± 1 dGA to acute isolation stress for one hour without visual, tactile, or auditory contact with their flockmates. UBF, blood pressure (BP), heart rate (HR), stress hormones, and blood gases were determined before and during this isolation challenge. Twenty-four hours later, experiments were repeated during alpha 1-adrenergic receptor blockage induced by a continuous intravenous infusion of urapidil. In both experiments, ewes reacted to isolation with an increase in serum norepinephrine, cortisol, BP, and HR as typical signs of activation of sympatho-adrenal and the hypothalamic-pituitary-adrenal axis. Stress-induced UBF decrease was prevented by alpha 1-adrenergic receptor blockage. We conclude that UBF decrease induced by maternal stress in sheep is mediated by alpha 1-adrenergic receptors. Future studies investigating prevention strategies of impact of prenatal maternal stress on fetal health should consider selective blockage of alpha 1-receptors to interrupt maternal-fetal stress transfer mediated by utero-placental malperfusion." @default.
- W2466395994 created "2016-07-22" @default.
- W2466395994 creator A5016603751 @default.
- W2466395994 creator A5020274366 @default.
- W2466395994 creator A5036552575 @default.
- W2466395994 creator A5049550553 @default.
- W2466395994 creator A5053513552 @default.
- W2466395994 creator A5055095906 @default.
- W2466395994 creator A5057183308 @default.
- W2466395994 creator A5069145317 @default.
- W2466395994 creator A5076530707 @default.
- W2466395994 creator A5086776003 @default.
- W2466395994 date "2016-07-17" @default.
- W2466395994 modified "2023-10-14" @default.
- W2466395994 title "Stress-induced decrease of uterine blood flow in sheep is mediated by alpha 1-adrenergic receptors" @default.
- W2466395994 cites W1824498374 @default.
- W2466395994 cites W1967981210 @default.
- W2466395994 cites W1990518668 @default.
- W2466395994 cites W2049150361 @default.
- W2466395994 cites W2056236208 @default.
- W2466395994 cites W2067255906 @default.
- W2466395994 cites W2102799765 @default.
- W2466395994 cites W2128458389 @default.
- W2466395994 cites W2129917462 @default.
- W2466395994 cites W307583063 @default.
- W2466395994 cites W4214568117 @default.
- W2466395994 doi "https://doi.org/10.1080/10253890.2016.1203417" @default.
- W2466395994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27352901" @default.
- W2466395994 hasPublicationYear "2016" @default.
- W2466395994 type Work @default.
- W2466395994 sameAs 2466395994 @default.
- W2466395994 citedByCount "11" @default.
- W2466395994 countsByYear W24663959942017 @default.
- W2466395994 countsByYear W24663959942018 @default.
- W2466395994 countsByYear W24663959942019 @default.
- W2466395994 countsByYear W24663959942020 @default.
- W2466395994 countsByYear W24663959942021 @default.
- W2466395994 countsByYear W24663959942022 @default.
- W2466395994 crossrefType "journal-article" @default.
- W2466395994 hasAuthorship W2466395994A5016603751 @default.
- W2466395994 hasAuthorship W2466395994A5020274366 @default.
- W2466395994 hasAuthorship W2466395994A5036552575 @default.
- W2466395994 hasAuthorship W2466395994A5049550553 @default.
- W2466395994 hasAuthorship W2466395994A5053513552 @default.
- W2466395994 hasAuthorship W2466395994A5055095906 @default.
- W2466395994 hasAuthorship W2466395994A5057183308 @default.
- W2466395994 hasAuthorship W2466395994A5069145317 @default.
- W2466395994 hasAuthorship W2466395994A5076530707 @default.
- W2466395994 hasAuthorship W2466395994A5086776003 @default.
- W2466395994 hasConcept C126322002 @default.
- W2466395994 hasConcept C134018914 @default.
- W2466395994 hasConcept C159110408 @default.
- W2466395994 hasConcept C170493617 @default.
- W2466395994 hasConcept C2775894120 @default.
- W2466395994 hasConcept C2775944032 @default.
- W2466395994 hasConcept C2778514916 @default.
- W2466395994 hasConcept C2779961880 @default.
- W2466395994 hasConcept C40465926 @default.
- W2466395994 hasConcept C49453240 @default.
- W2466395994 hasConcept C513476851 @default.
- W2466395994 hasConcept C64943373 @default.
- W2466395994 hasConcept C71924100 @default.
- W2466395994 hasConceptScore W2466395994C126322002 @default.
- W2466395994 hasConceptScore W2466395994C134018914 @default.
- W2466395994 hasConceptScore W2466395994C159110408 @default.
- W2466395994 hasConceptScore W2466395994C170493617 @default.
- W2466395994 hasConceptScore W2466395994C2775894120 @default.
- W2466395994 hasConceptScore W2466395994C2775944032 @default.
- W2466395994 hasConceptScore W2466395994C2778514916 @default.
- W2466395994 hasConceptScore W2466395994C2779961880 @default.
- W2466395994 hasConceptScore W2466395994C40465926 @default.
- W2466395994 hasConceptScore W2466395994C49453240 @default.
- W2466395994 hasConceptScore W2466395994C513476851 @default.
- W2466395994 hasConceptScore W2466395994C64943373 @default.
- W2466395994 hasConceptScore W2466395994C71924100 @default.
- W2466395994 hasIssue "5" @default.
- W2466395994 hasLocation W24663959941 @default.
- W2466395994 hasLocation W24663959942 @default.
- W2466395994 hasOpenAccess W2466395994 @default.
- W2466395994 hasPrimaryLocation W24663959941 @default.
- W2466395994 hasRelatedWork W1978175539 @default.
- W2466395994 hasRelatedWork W1983321239 @default.
- W2466395994 hasRelatedWork W1993741635 @default.
- W2466395994 hasRelatedWork W2039472462 @default.
- W2466395994 hasRelatedWork W2052453588 @default.
- W2466395994 hasRelatedWork W2058256587 @default.
- W2466395994 hasRelatedWork W2079376440 @default.
- W2466395994 hasRelatedWork W2142711007 @default.
- W2466395994 hasRelatedWork W2169102024 @default.
- W2466395994 hasRelatedWork W4237202289 @default.
- W2466395994 hasVolume "19" @default.
- W2466395994 isParatext "false" @default.
- W2466395994 isRetracted "false" @default.
- W2466395994 magId "2466395994" @default.
- W2466395994 workType "article" @default.