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- W2466408091 endingPage "1682" @default.
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- W2466408091 abstract "Introduction: Amyotrophic lateral sclerosis (ALS), one in a family of age-related neurodegenerative disorders, is marked by predominantly cryptogenic causes, partially elucidated pathophysiology, and elusive treatments. The challenges of ALS are illustrated by two decades of negative drug trials.Areas covered: In this article, we lay out the current understanding of disease genesis and physiology in relation to drug development in ALS, stressing important accomplishments and gaps in knowledge. We briefly consider clinical ALS, the ongoing search for biomarkers, and the latest in trial design, highlighting major recent and ongoing clinical trials; and we discuss, in a concluding section on future directions, the prion-protein hypothesis of neurodegeneration and what steps can be taken to end the drought that has characterized drug discovery in ALS.Expert opinion: Age-related neurodegenerative disorders are fast becoming major public health problems for the world’s aging populations. Several agents offer promise in the near-term, but drug development is hampered by an interrelated cycle of obstacles surrounding etiological, physiological, and biomarkers discovery. It is time for the type of government-funded, public-supported offensive on neurodegenerative disease that has been effective in other fields." @default.
- W2466408091 created "2016-07-22" @default.
- W2466408091 creator A5018673463 @default.
- W2466408091 creator A5024570101 @default.
- W2466408091 creator A5047889563 @default.
- W2466408091 creator A5063925465 @default.
- W2466408091 creator A5083897192 @default.
- W2466408091 date "2016-07-04" @default.
- W2466408091 modified "2023-09-26" @default.
- W2466408091 title "Amyotrophic Lateral Sclerosis, 2016: existing therapies and the ongoing search for neuroprotection" @default.
- W2466408091 cites W1480524493 @default.
- W2466408091 cites W1490263589 @default.
- W2466408091 cites W1511318907 @default.
- W2466408091 cites W1557794136 @default.
- W2466408091 cites W1558795029 @default.
- W2466408091 cites W1613946354 @default.
- W2466408091 cites W1941286758 @default.
- W2466408091 cites W1964211967 @default.
- W2466408091 cites W1965434700 @default.
- W2466408091 cites W1965935009 @default.
- W2466408091 cites W1967247929 @default.
- W2466408091 cites W1967922486 @default.
- W2466408091 cites W1968840823 @default.
- W2466408091 cites W1969850018 @default.
- W2466408091 cites W1971186749 @default.
- W2466408091 cites W1972605674 @default.
- W2466408091 cites W1973771042 @default.
- W2466408091 cites W1974240968 @default.
- W2466408091 cites W1977785286 @default.
- W2466408091 cites W1978978943 @default.
- W2466408091 cites W1981295136 @default.
- W2466408091 cites W1982523116 @default.
- W2466408091 cites W1984218351 @default.
- W2466408091 cites W1984308849 @default.
- W2466408091 cites W1985582661 @default.
- W2466408091 cites W1986834353 @default.
- W2466408091 cites W1988545157 @default.
- W2466408091 cites W1990057142 @default.
- W2466408091 cites W1991208268 @default.
- W2466408091 cites W1994243437 @default.
- W2466408091 cites W1995885857 @default.
- W2466408091 cites W1996620174 @default.
- W2466408091 cites W1999638129 @default.
- W2466408091 cites W1999732659 @default.
- W2466408091 cites W2001432662 @default.
- W2466408091 cites W2001610698 @default.
- W2466408091 cites W2001909063 @default.
- W2466408091 cites W2002071227 @default.
- W2466408091 cites W2002215733 @default.
- W2466408091 cites W2003205286 @default.
- W2466408091 cites W2003618511 @default.
- W2466408091 cites W2004439628 @default.
- W2466408091 cites W2005508991 @default.
- W2466408091 cites W2007027598 @default.
- W2466408091 cites W2007478642 @default.
- W2466408091 cites W2008646706 @default.
- W2466408091 cites W2009020263 @default.
- W2466408091 cites W2009108898 @default.
- W2466408091 cites W2011206748 @default.
- W2466408091 cites W2011439532 @default.
- W2466408091 cites W2013135033 @default.
- W2466408091 cites W2016010006 @default.
- W2466408091 cites W2017587030 @default.
- W2466408091 cites W2021830011 @default.
- W2466408091 cites W2021970714 @default.
- W2466408091 cites W2022522003 @default.
- W2466408091 cites W2022925950 @default.
- W2466408091 cites W2024118360 @default.
- W2466408091 cites W2026980091 @default.
- W2466408091 cites W2028298072 @default.
- W2466408091 cites W2030524276 @default.
- W2466408091 cites W2030893485 @default.
- W2466408091 cites W2030932792 @default.
- W2466408091 cites W2031700674 @default.
- W2466408091 cites W2032734645 @default.
- W2466408091 cites W2033528195 @default.
- W2466408091 cites W2034383806 @default.
- W2466408091 cites W2034454495 @default.
- W2466408091 cites W2034962152 @default.
- W2466408091 cites W2035016723 @default.
- W2466408091 cites W2036537324 @default.
- W2466408091 cites W2037438288 @default.
- W2466408091 cites W2040937200 @default.
- W2466408091 cites W2044799628 @default.
- W2466408091 cites W2045151039 @default.
- W2466408091 cites W2045319154 @default.
- W2466408091 cites W2045990314 @default.
- W2466408091 cites W2046888375 @default.
- W2466408091 cites W2048599666 @default.
- W2466408091 cites W2048891340 @default.
- W2466408091 cites W2049349799 @default.
- W2466408091 cites W2050626075 @default.
- W2466408091 cites W2052332287 @default.
- W2466408091 cites W2054693618 @default.
- W2466408091 cites W2055270946 @default.
- W2466408091 cites W2055355861 @default.
- W2466408091 cites W2057119353 @default.
- W2466408091 cites W2058112065 @default.