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• W2466411552 abstract "A combined study of light and electron microscopy and of immunolabelling of three pleomorphic spindle cell sarcomas is presented. The light and electron microscopic features of these sarcomas were most compatible with those described for malignant fibrous histiocytoma (MFH, pleomorphic-storiform subtype). Electronmicroscopically undifferentiated and fibroblast-like cells, fibrohistiocytes and multinucleated histiocytes were observed. Characteristics belonging to smooth muscle cells were absent. By immunostaining, vimentin and desmin could be observed in tumour cells of all three cases, at least on frozen sections. Other markers such as alpha 1-antichymotrypsin, S-100 proteins, laminin, collagen IV and markers specific for skeletal muscle cells (myoglobin, actin and myosin specific for skeletal muscle) could not be demonstrated. These findings indicate that three MFH's are, in fact, poorly differentiated variants of smooth muscle tumours. It is concluded that immunophenotyping is very useful for this type of neoplasm." @default.
• W2466411552 created "2016-07-22" @default.
• W2466411552 creator A5022071251 @default.
• W2466411552 creator A5025166197 @default.
• W2466411552 creator A5044400719 @default.
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• W2466411552 date "1988-10-01" @default.
• W2466411552 modified "2023-09-23" @default.
• W2466411552 title "Leiomyosarcomas: three cases with desmin positive tumour cells, lacking ultrastructural features of smooth muscle cells." @default.
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• W2466411552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2980248" @default.
• W2466411552 hasPublicationYear "1988" @default.
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