Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466474911> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2466474911 endingPage "80" @default.
- W2466474911 startingPage "365" @default.
- W2466474911 abstract "Pharmacogenetics involves research into the hereditary basis for the different responses of different individuals to drugs or other environmental pollutants. Circumstantial evidence from a growing number of laboratory animal model systems suggests that human susceptibility to environmentally caused cancers may be influenced by an underlying genetic predisposition for metabolism of drugs and other foreign chemicals. The Ah locus is an example of a well-characterized model system for studying pharmacogenetics in mice. This complex controls the induction by polycyclic aromatic compounds of numerous drug-metabolizing enzyme 'activities'. Allelic differences at the Ah locus have been shown to be associated in the mouse with increased individual risk for cancer, mutation, DNA binding of reactive metabolites, drug toxicity, birth defects and enhanced detoxication. These differences appear to reflect changes in the steady-state level of reactive intermediates in target tissues. Tissue sites in direct contact with the carcinogen develop cancer more readily in responsive animals because of the presence of induced P1-450; tissues at distant sites of the body may develop malignancy more readily in nonresponsive animals because more carcinogen reaches that tissue, due to decreased P1-450 induction in proximal tissues and, therefore, a decrease in detoxication. Hence, not only the dose but the route of administration, the timing of the dosage, and the site of the tumour or toxicity--relative to the site of administered drug--are all very important in the interpretation of data from carcinogenicity or toxicity experiments involving P1-450 inducers, such as polycyclic hydrocarbons. These data emphasize the utility of studies in intact animals, in which differences in pharmacokinetics and enzyme induction may occur among various tissues; such subtleties cannot be detected in short-term testing with bacteria or tissue cultures. There is sufficient evidence that heritable variation of the Ah complex occurs in man. With the advent of recombinant DNA technology, this laboratory has recently cloned the P1-450 gene. In addition to a better understanding of P-450 induction and evolution of P-450 genes, we hope to develop a more sensitive assay for assessing the human Ah phenotype." @default.
- W2466474911 created "2016-07-22" @default.
- W2466474911 creator A5031951388 @default.
- W2466474911 date "1982-01-01" @default.
- W2466474911 modified "2023-09-23" @default.
- W2466474911 title "Pharmacogenetics and human cancer." @default.
- W2466474911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7152614" @default.
- W2466474911 hasPublicationYear "1982" @default.
- W2466474911 type Work @default.
- W2466474911 sameAs 2466474911 @default.
- W2466474911 citedByCount "3" @default.
- W2466474911 crossrefType "journal-article" @default.
- W2466474911 hasAuthorship W2466474911A5031951388 @default.
- W2466474911 hasConcept C104317684 @default.
- W2466474911 hasConcept C114246631 @default.
- W2466474911 hasConcept C121608353 @default.
- W2466474911 hasConcept C126322002 @default.
- W2466474911 hasConcept C135763542 @default.
- W2466474911 hasConcept C180754005 @default.
- W2466474911 hasConcept C181199279 @default.
- W2466474911 hasConcept C2778236027 @default.
- W2466474911 hasConcept C2778959862 @default.
- W2466474911 hasConcept C2780035454 @default.
- W2466474911 hasConcept C29730261 @default.
- W2466474911 hasConcept C33070731 @default.
- W2466474911 hasConcept C54355233 @default.
- W2466474911 hasConcept C55493867 @default.
- W2466474911 hasConcept C55775858 @default.
- W2466474911 hasConcept C67636389 @default.
- W2466474911 hasConcept C71924100 @default.
- W2466474911 hasConcept C86803240 @default.
- W2466474911 hasConcept C89311334 @default.
- W2466474911 hasConcept C98274493 @default.
- W2466474911 hasConceptScore W2466474911C104317684 @default.
- W2466474911 hasConceptScore W2466474911C114246631 @default.
- W2466474911 hasConceptScore W2466474911C121608353 @default.
- W2466474911 hasConceptScore W2466474911C126322002 @default.
- W2466474911 hasConceptScore W2466474911C135763542 @default.
- W2466474911 hasConceptScore W2466474911C180754005 @default.
- W2466474911 hasConceptScore W2466474911C181199279 @default.
- W2466474911 hasConceptScore W2466474911C2778236027 @default.
- W2466474911 hasConceptScore W2466474911C2778959862 @default.
- W2466474911 hasConceptScore W2466474911C2780035454 @default.
- W2466474911 hasConceptScore W2466474911C29730261 @default.
- W2466474911 hasConceptScore W2466474911C33070731 @default.
- W2466474911 hasConceptScore W2466474911C54355233 @default.
- W2466474911 hasConceptScore W2466474911C55493867 @default.
- W2466474911 hasConceptScore W2466474911C55775858 @default.
- W2466474911 hasConceptScore W2466474911C67636389 @default.
- W2466474911 hasConceptScore W2466474911C71924100 @default.
- W2466474911 hasConceptScore W2466474911C86803240 @default.
- W2466474911 hasConceptScore W2466474911C89311334 @default.
- W2466474911 hasConceptScore W2466474911C98274493 @default.
- W2466474911 hasIssue "39" @default.
- W2466474911 hasLocation W24664749111 @default.
- W2466474911 hasOpenAccess W2466474911 @default.
- W2466474911 hasPrimaryLocation W24664749111 @default.
- W2466474911 hasRelatedWork W2023487034 @default.
- W2466474911 hasRelatedWork W2080489638 @default.
- W2466474911 hasRelatedWork W2088436316 @default.
- W2466474911 hasRelatedWork W2102920107 @default.
- W2466474911 hasRelatedWork W211573666 @default.
- W2466474911 hasRelatedWork W2116543832 @default.
- W2466474911 hasRelatedWork W2313850145 @default.
- W2466474911 hasRelatedWork W2466474911 @default.
- W2466474911 hasRelatedWork W60749247 @default.
- W2466474911 hasRelatedWork W72732335 @default.
- W2466474911 isParatext "false" @default.
- W2466474911 isRetracted "false" @default.
- W2466474911 magId "2466474911" @default.
- W2466474911 workType "article" @default.