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• W2466475304 startingPage "23" @default.
• W2466475304 abstract "The majority of the remarkable progress in understanding the molecular pathogenesis of Pulmonary Arterial Hypertension has been achieved within the past 2 decades. But despite important advances in treatment, PAH remains a disease with poor survival and no curative therapy. A rapidly growing molecular knowledge base provides hope for the possibility to develop specific therapies targeted at the origins of disease, as well as factors which modify therapeutic response. In this synopsis, we summarize highlights of the genetic basis of PAH, and the evolving fields of prediction of disease risk, its course, and response to specific treatments in individual PAH patients. Further, we summarize the major advances of gene editing approaches which promise a new era of intervention, which is now in its infancy but likely to advance rapidly." @default.
• W2466475304 created "2016-07-22" @default.
• W2466475304 creator A5030467856 @default.
• W2466475304 creator A5042419219 @default.
• W2466475304 creator A5056044508 @default.
• W2466475304 creator A5065762639 @default.
• W2466475304 date "2017-01-01" @default.
• W2466475304 modified "2023-10-14" @default.
• W2466475304 title "T<scp>ranslational</scp> A<scp>dvances</scp> <scp>in</scp> <scp>the</scp> F<scp>ield</scp> <scp>of</scp> P<scp>ulmonary</scp> H<scp>ypertension</scp> Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to Precision Medicine and Gene Editing" @default.
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• W2466475304 doi "https://doi.org/10.1164/rccm.201605-0905pp" @default.
• W2466475304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5214922" @default.
• W2466475304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27398627" @default.
• W2466475304 hasPublicationYear "2017" @default.
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