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- W2466508749 endingPage "561" @default.
- W2466508749 startingPage "543" @default.
- W2466508749 abstract "At present, it appears abundantly clear that thyroid hormone exerts its major action at the nuclear level by regulating the level of mRNAs of specific genes. There are at least three TR isoforms that mediate hormonal effects at the tissue level. Characterization of the functional domains of these receptor isoforms is as yet incomplete, and the possibility that these receptors could have ligand-independent functions is a matter under current investigation. TRs are now recognized as members of a large superfamily of transactivating proteins involved in the regulation of gene expression. Recent studies have shown an unexpected degree of complexity in the nature of the association of the T3 receptors and the DNA of target genes. They have vividly pointed out the multiple interactions possible between the T3-receptor complex and other proteins participating in the process of gene regulation. These insights have provided a solid base for understanding differences in the gradation of thyroid hormone effect from one tissue to another. The microdissection of the molecular process that has occurred in the past 20 years has proceeded in part through the application of relatively artificial in vitro systems and assays. Whereas such approaches have undoubtedly reaped rich rewards in pointing out potential or possible mechanisms, they do not define the actual workings in the animal. Additional studies designed to examine at the molecular level the operation in vivo of physiologic networks influenced by thyroid hormones appear as an essential next step in understanding the biology of the hormone system. The application of transgenic models should materially assist such efforts." @default.
- W2466508749 created "2016-07-22" @default.
- W2466508749 creator A5059616408 @default.
- W2466508749 creator A5068059911 @default.
- W2466508749 creator A5081208916 @default.
- W2466508749 date "1993-09-01" @default.
- W2466508749 modified "2023-09-27" @default.
- W2466508749 title "Molecular Mechanisms of Thyroid Hormone Action: A Physiologic Perspective" @default.
- W2466508749 cites W1483275313 @default.
- W2466508749 cites W1498239088 @default.
- W2466508749 cites W1514956241 @default.
- W2466508749 cites W1517725951 @default.
- W2466508749 cites W1517784889 @default.
- W2466508749 cites W1531051035 @default.
- W2466508749 cites W1533577815 @default.
- W2466508749 cites W1540400224 @default.
- W2466508749 cites W1556745820 @default.
- W2466508749 cites W1565592850 @default.
- W2466508749 cites W1568323065 @default.
- W2466508749 cites W1581439266 @default.
- W2466508749 cites W1583328345 @default.
- W2466508749 cites W1587846326 @default.
- W2466508749 cites W1593924964 @default.
- W2466508749 cites W1602088802 @default.
- W2466508749 cites W1604985295 @default.
- W2466508749 cites W1610294927 @default.
- W2466508749 cites W1628693640 @default.
- W2466508749 cites W1670076014 @default.
- W2466508749 cites W1758817371 @default.
- W2466508749 cites W1919826524 @default.
- W2466508749 cites W1965735992 @default.
- W2466508749 cites W1971263640 @default.
- W2466508749 cites W1974639601 @default.
- W2466508749 cites W1975141307 @default.
- W2466508749 cites W1976030054 @default.
- W2466508749 cites W1976499539 @default.
- W2466508749 cites W1979544459 @default.
- W2466508749 cites W1983450433 @default.
- W2466508749 cites W1984557292 @default.
- W2466508749 cites W1986006697 @default.
- W2466508749 cites W1988629919 @default.
- W2466508749 cites W1989802611 @default.
- W2466508749 cites W1990675136 @default.
- W2466508749 cites W1992289621 @default.
- W2466508749 cites W1996380266 @default.
- W2466508749 cites W2000906823 @default.
- W2466508749 cites W2002235717 @default.
- W2466508749 cites W2002712696 @default.
- W2466508749 cites W2005914718 @default.
- W2466508749 cites W2007169317 @default.
- W2466508749 cites W2007638374 @default.
- W2466508749 cites W2009885066 @default.
- W2466508749 cites W2011467252 @default.
- W2466508749 cites W2015229933 @default.
- W2466508749 cites W2016009447 @default.
- W2466508749 cites W2016458297 @default.
- W2466508749 cites W2017117462 @default.
- W2466508749 cites W2019705832 @default.
- W2466508749 cites W2023089345 @default.
- W2466508749 cites W2023552937 @default.
- W2466508749 cites W2028549678 @default.
- W2466508749 cites W2037861531 @default.
- W2466508749 cites W2037961015 @default.
- W2466508749 cites W2038586333 @default.
- W2466508749 cites W2039320951 @default.
- W2466508749 cites W2040911557 @default.
- W2466508749 cites W2041277420 @default.
- W2466508749 cites W2050874067 @default.
- W2466508749 cites W2057093659 @default.
- W2466508749 cites W2058232931 @default.
- W2466508749 cites W2061484507 @default.
- W2466508749 cites W2063110155 @default.
- W2466508749 cites W2067420064 @default.
- W2466508749 cites W2068609431 @default.
- W2466508749 cites W2068731305 @default.
- W2466508749 cites W2073919574 @default.
- W2466508749 cites W2075232957 @default.
- W2466508749 cites W2075788654 @default.
- W2466508749 cites W2077580619 @default.
- W2466508749 cites W2078724152 @default.
- W2466508749 cites W2080046379 @default.
- W2466508749 cites W2080980412 @default.
- W2466508749 cites W2081585400 @default.
- W2466508749 cites W2082063013 @default.
- W2466508749 cites W2083979618 @default.
- W2466508749 cites W2085124463 @default.
- W2466508749 cites W2086609865 @default.
- W2466508749 cites W2089212277 @default.
- W2466508749 cites W2090024435 @default.
- W2466508749 cites W2094973122 @default.
- W2466508749 cites W2112823160 @default.
- W2466508749 cites W2112897084 @default.
- W2466508749 cites W2119671728 @default.
- W2466508749 cites W2120176836 @default.
- W2466508749 cites W2123522152 @default.
- W2466508749 cites W2124848712 @default.
- W2466508749 cites W2131695882 @default.
- W2466508749 cites W2132573692 @default.