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- W2466554265 abstract "The surface chemistry of the cell membrane plays an important role in how cells interact with particulate species. These interactions are dictated in large part by lipid headgroup charge. To investigate the nature of electrostatic interactions between lipid bilayers and nanoparticles in solution, we investigated nanoparticles interacting with lipids in which the zwitterionic head group was inverted from its natural configuration. This inverted lipid species, referred to as DOCP, is based on 1,2-dioleoyl-glycero-3-phosphocholine (DOPC) but has the positions of the phosphate and choline groups reversed. Membrane interactions with nanoparticles were investigated by forming giant unilamellar vesicles (GUVs) and introducing differently charged nanoparticles to both DOPC GUVs and DOCP GUVs. GUVs in the presence of nanoparticles displayed various deformational modes including contraction, budding, and even rupture. The differences in responses between the two lipid species investigated illuminate how the relative positions of the phosphate and amine groups contribute to the nanoparticle-membrane electrostatic interaction. This provides fundamental insights regarding the nature of this interaction, which has implications for the development of new drug delivery vehicles as well as the environmental toxicity of nanomaterials." @default.
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- W2466554265 date "2016-02-01" @default.
- W2466554265 modified "2023-09-29" @default.
- W2466554265 title "Nanoparticle Interactions with Giant Vesicles Fabricated from Inverted Headgroup Lipids" @default.
- W2466554265 doi "https://doi.org/10.1016/j.bpj.2015.11.1333" @default.
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