FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466656992> ?p ?o ?g. }

• W2466656992 endingPage "1881" @default.
• W2466656992 startingPage "1876" @default.
• W2466656992 abstract "Manganese is both an essential element and a known toxicant, and it plays important roles in many mechanisms in relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare.We investigated the association between plasma manganese and newly diagnosed T2D as well as whether the association could be modified by manganese superoxide dismutase (MnSOD) polymorphisms.We conducted a case-control study of 3,228 participants in China: 1,614 T2D patients and 1,614 controls. Concentrations of plasma magnesium were measured, and all participants were genotyped for the MnSOD Val16Ala polymorphism (rs4880).A U-shaped association was observed between plasma manganese and T2D, with increased odds ratios (ORs) in relation to either low or high plasma manganese levels. Compared with the middle tertile, the multivariate-adjusted ORs [95% confidence intervals (CIs)] of T2D associated with the lowest tertile and the highest tertile of plasma manganese were 1.89 (1.53, 2.33) and 1.56 (1.23, 1.97), respectively. In spline analysis, the U-shaped association was consistently indicated, with the lowest odds of T2D at the plasma manganese concentration of 4.95 μg/L. Minor allele frequencies (C allele) of the MnSOD Val16Ala polymorphism (rs4880) in the normal glucose tolerance (NGT) and the T2D groups were 13.57% and 14.50%, respectively. The MnSOD rs4880 polymorphism was not associated with T2D, and no interaction was found between plasma manganese and the MnSOD rs4880 polymorphism in relation to T2D.Our results suggested a U-shaped association between plasma manganese and T2D; both low and high levels of plasma manganese were associated with higher odds of newly diagnosed T2D. The U-shaped association was not modified by the MnSOD rs4880 polymorphism. Citation: Shan Z, Chen S, Sun T, Luo C, Guo Y, Yu X, Yang W, Hu FB, Liu L. 2016. U-shaped association between plasma manganese levels and type 2 diabetes. Environ Health Perspect 124:1876-1881; http://dx.doi.org/10.1289/EHP176." @default.
• W2466656992 created "2016-07-22" @default.
• W2466656992 creator A5007067761 @default.
• W2466656992 creator A5024637740 @default.
• W2466656992 creator A5027310979 @default.
• W2466656992 creator A5028072550 @default.
• W2466656992 creator A5042831915 @default.
• W2466656992 creator A5052332217 @default.
• W2466656992 creator A5056459536 @default.
• W2466656992 creator A5070069653 @default.
• W2466656992 creator A5073699430 @default.
• W2466656992 date "2016-12-01" @default.
• W2466656992 modified "2023-10-16" @default.
• W2466656992 title "U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes" @default.
• W2466656992 cites W1725124326 @default.
• W2466656992 cites W1835739429 @default.
• W2466656992 cites W1921895525 @default.
• W2466656992 cites W1964548658 @default.
• W2466656992 cites W1967964480 @default.
• W2466656992 cites W1970630357 @default.
• W2466656992 cites W1971891953 @default.
• W2466656992 cites W1971906792 @default.
• W2466656992 cites W1972393885 @default.
• W2466656992 cites W1973441383 @default.
• W2466656992 cites W1973870797 @default.
• W2466656992 cites W1988906112 @default.
• W2466656992 cites W1995940893 @default.
• W2466656992 cites W1996205861 @default.
• W2466656992 cites W1996304309 @default.
• W2466656992 cites W2001003591 @default.
• W2466656992 cites W2004714156 @default.
• W2466656992 cites W2005348427 @default.
• W2466656992 cites W2007813076 @default.
• W2466656992 cites W2028419296 @default.
• W2466656992 cites W2030845275 @default.
• W2466656992 cites W2038018821 @default.
• W2466656992 cites W2038833526 @default.
• W2466656992 cites W2059407142 @default.
• W2466656992 cites W2059467226 @default.
• W2466656992 cites W2060181072 @default.
• W2466656992 cites W2060431825 @default.
• W2466656992 cites W2064257351 @default.
• W2466656992 cites W2068558742 @default.
• W2466656992 cites W207128951 @default.
• W2466656992 cites W2077180083 @default.
• W2466656992 cites W2077722171 @default.
• W2466656992 cites W2080626648 @default.
• W2466656992 cites W2084610168 @default.
• W2466656992 cites W2093418656 @default.
• W2466656992 cites W2106775688 @default.
• W2466656992 cites W2107849763 @default.
• W2466656992 cites W2110657098 @default.
• W2466656992 cites W2112672163 @default.
• W2466656992 cites W2114111268 @default.
• W2466656992 cites W2114443210 @default.
• W2466656992 cites W2116989009 @default.
• W2466656992 cites W2121452915 @default.
• W2466656992 cites W2127998841 @default.
• W2466656992 cites W2130066939 @default.
• W2466656992 cites W2134293572 @default.
• W2466656992 cites W2138714173 @default.
• W2466656992 cites W2144711788 @default.
• W2466656992 cites W2148641840 @default.
• W2466656992 cites W2155793985 @default.
• W2466656992 cites W2160234571 @default.
• W2466656992 cites W2161479914 @default.
• W2466656992 cites W2161569099 @default.
• W2466656992 cites W2172261221 @default.
• W2466656992 cites W2192080449 @default.
• W2466656992 cites W2404358683 @default.
• W2466656992 cites W2607031541 @default.
• W2466656992 cites W4237857420 @default.
• W2466656992 cites W581981666 @default.
• W2466656992 doi "https://doi.org/10.1289/ehp176" @default.
• W2466656992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5132633" @default.
• W2466656992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27258818" @default.
• W2466656992 hasPublicationYear "2016" @default.
• W2466656992 type Work @default.
• W2466656992 sameAs 2466656992 @default.
• W2466656992 citedByCount "52" @default.
• W2466656992 countsByYear W24666569922017 @default.
• W2466656992 countsByYear W24666569922018 @default.
• W2466656992 countsByYear W24666569922019 @default.
• W2466656992 countsByYear W24666569922020 @default.
• W2466656992 countsByYear W24666569922021 @default.
• W2466656992 countsByYear W24666569922022 @default.
• W2466656992 countsByYear W24666569922023 @default.
• W2466656992 crossrefType "journal-article" @default.
• W2466656992 hasAuthorship W2466656992A5007067761 @default.
• W2466656992 hasAuthorship W2466656992A5024637740 @default.
• W2466656992 hasAuthorship W2466656992A5027310979 @default.
• W2466656992 hasAuthorship W2466656992A5028072550 @default.
• W2466656992 hasAuthorship W2466656992A5042831915 @default.
• W2466656992 hasAuthorship W2466656992A5052332217 @default.
• W2466656992 hasAuthorship W2466656992A5056459536 @default.
• W2466656992 hasAuthorship W2466656992A5070069653 @default.
• W2466656992 hasAuthorship W2466656992A5073699430 @default.
• W2466656992 hasBestOaLocation W24666569921 @default.

• next