FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466657922> ?p ?o ?g. }

• W2466657922 endingPage "1502" @default.
• W2466657922 startingPage "1493" @default.
• W2466657922 abstract "BackgroundThe hepatocyte growth factor receptor gene (MET) exon 14 skipping (METex14) has recently been described a potential driver alteration in lung cancer targetable by mesenchymal-to-epithelial transition factor (MET) tyrosine kinase inhibitors (TKIs).MethodsWell-validated hybrid capture–based comprehensive genomic profiling was performed at the request of individual treating physicians.ResultsOf 11,205 lung cancers profiled by comprehensive genomic profiling, 298 (2.7%) carcinomas harbored alterations predicted to cause METex14, including adenosquamous (8.2%), sarcomatoid (7.7%), histologic subtype not otherwise specified (3.0%), adenocarcinoma (2.9%), squamous cell (2.1%), large cell (0.8%), and SCLC (0.2%). Acinar features were present in 24% of the METex14 samples. Six cases (2%) harbored MET Y1003X mutations affecting binding of the MET-negative regulator, E3 ubiquitin protein ligase. The median age of all patients with METex14 was 73 years (range 43–95) and 60% were female. Concurrent, murine double minute gene (MDM2) amplification, cyclin-dependent kinase 4 gene (CDK4) amplification, and EGFR amplification were observed in 35%, 21%, and 6.4% of patients with METex14, respectively. KRAS mutation was observed in 3% of cases. Concurrent MET amplification (METamp) (median copy number 10) was identified in 15% of METex14 samples. Significant differences in tumor mutational burden and type of the METex14 alterations were observed between the METamp and non-METamp samples. Response to MET TKI was observed in both in patients with METamp and in patients without METamp METex14.ConclusionDiverse targetable METex14 alterations were identified in patients with NSCLC across age groups, including elderly patients, and in all major NSCLC histologic subtypes with an overall frequency of 2.7%. These findings support the use of hybrid capture–based molecular profiling across NSCLC subtypes to identify patients who will potentially benefit from MET TKIs." @default.
• W2466657922 created "2016-07-22" @default.
• W2466657922 creator A5004186373 @default.
• W2466657922 creator A5011609796 @default.
• W2466657922 creator A5021626755 @default.
• W2466657922 creator A5033808702 @default.
• W2466657922 creator A5035120516 @default.
• W2466657922 creator A5036134937 @default.
• W2466657922 creator A5041640815 @default.
• W2466657922 creator A5048608729 @default.
• W2466657922 creator A5051868448 @default.
• W2466657922 creator A5059543131 @default.
• W2466657922 creator A5062019987 @default.
• W2466657922 creator A5066306817 @default.
• W2466657922 creator A5070079018 @default.
• W2466657922 creator A5075838996 @default.
• W2466657922 creator A5081356537 @default.
• W2466657922 creator A5088559019 @default.
• W2466657922 creator A5088809839 @default.
• W2466657922 date "2016-09-01" @default.
• W2466657922 modified "2023-10-18" @default.
• W2466657922 title "Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations" @default.
• W2466657922 cites W1892652546 @default.
• W2466657922 cites W1930367058 @default.
• W2466657922 cites W1974203897 @default.
• W2466657922 cites W1998378449 @default.
• W2466657922 cites W2039491462 @default.
• W2466657922 cites W2056187710 @default.
• W2466657922 cites W2056837471 @default.
• W2466657922 cites W2065477010 @default.
• W2466657922 cites W2096483233 @default.
• W2466657922 cites W2100991907 @default.
• W2466657922 cites W2103934990 @default.
• W2466657922 cites W2121262970 @default.
• W2466657922 cites W2138309116 @default.
• W2466657922 cites W2144539352 @default.
• W2466657922 cites W2152735604 @default.
• W2466657922 cites W2158477153 @default.
• W2466657922 cites W2159426719 @default.
• W2466657922 cites W2160212814 @default.
• W2466657922 cites W2160725767 @default.
• W2466657922 cites W2160981405 @default.
• W2466657922 cites W2180481128 @default.
• W2466657922 cites W2230948985 @default.
• W2466657922 cites W2259419843 @default.
• W2466657922 cites W2272081149 @default.
• W2466657922 cites W2303903837 @default.
• W2466657922 cites W2327451947 @default.
• W2466657922 doi "https://doi.org/10.1016/j.jtho.2016.06.004" @default.
• W2466657922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27343443" @default.
• W2466657922 hasPublicationYear "2016" @default.
• W2466657922 type Work @default.
• W2466657922 sameAs 2466657922 @default.
• W2466657922 citedByCount "266" @default.
• W2466657922 countsByYear W24666579222016 @default.
• W2466657922 countsByYear W24666579222017 @default.
• W2466657922 countsByYear W24666579222018 @default.
• W2466657922 countsByYear W24666579222019 @default.
• W2466657922 countsByYear W24666579222020 @default.
• W2466657922 countsByYear W24666579222021 @default.
• W2466657922 countsByYear W24666579222022 @default.
• W2466657922 countsByYear W24666579222023 @default.
• W2466657922 crossrefType "journal-article" @default.
• W2466657922 hasAuthorship W2466657922A5004186373 @default.
• W2466657922 hasAuthorship W2466657922A5011609796 @default.
• W2466657922 hasAuthorship W2466657922A5021626755 @default.
• W2466657922 hasAuthorship W2466657922A5033808702 @default.
• W2466657922 hasAuthorship W2466657922A5035120516 @default.
• W2466657922 hasAuthorship W2466657922A5036134937 @default.
• W2466657922 hasAuthorship W2466657922A5041640815 @default.
• W2466657922 hasAuthorship W2466657922A5048608729 @default.
• W2466657922 hasAuthorship W2466657922A5051868448 @default.
• W2466657922 hasAuthorship W2466657922A5059543131 @default.
• W2466657922 hasAuthorship W2466657922A5062019987 @default.
• W2466657922 hasAuthorship W2466657922A5066306817 @default.
• W2466657922 hasAuthorship W2466657922A5070079018 @default.
• W2466657922 hasAuthorship W2466657922A5075838996 @default.
• W2466657922 hasAuthorship W2466657922A5081356537 @default.
• W2466657922 hasAuthorship W2466657922A5088559019 @default.
• W2466657922 hasAuthorship W2466657922A5088809839 @default.
• W2466657922 hasBestOaLocation W24666579221 @default.
• W2466657922 hasConcept C104317684 @default.
• W2466657922 hasConcept C121608353 @default.
• W2466657922 hasConcept C126322002 @default.
• W2466657922 hasConcept C143998085 @default.
• W2466657922 hasConcept C2775999482 @default.
• W2466657922 hasConcept C2776232967 @default.
• W2466657922 hasConcept C2776256026 @default.
• W2466657922 hasConcept C2779422266 @default.
• W2466657922 hasConcept C2781182431 @default.
• W2466657922 hasConcept C2781187634 @default.
• W2466657922 hasConcept C36823959 @default.
• W2466657922 hasConcept C502942594 @default.
• W2466657922 hasConcept C526805850 @default.
• W2466657922 hasConcept C54355233 @default.
• W2466657922 hasConcept C71924100 @default.
• W2466657922 hasConcept C7602840 @default.
• W2466657922 hasConcept C86803240 @default.

• next