FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466671112> ?p ?o ?g. }

• W2466671112 endingPage "C507" @default.
• W2466671112 startingPage "C498" @default.
• W2466671112 abstract "Microfold (M) cells are phagocytic intestinal epithelial cells in the follicle-associated epithelium of Peyer's patches that transport particulate antigens from the gut lumen into the subepithelial dome. Differentiation of M cells from epithelial stem cells in intestinal crypts requires the cytokine receptor activator of NF-κB ligand (RANKL) and the transcription factor Spi-B. We used three-dimensional enteroid cultures established with small intestinal crypts from mice as a model system to investigate signaling pathways involved in M cell differentiation and the influence of other cytokines on RANKL-induced M cell differentiation. Addition of RANKL to enteroids induced expression of multiple M cell-associated genes, including Spib, Ccl9 [chemokine (C-C motif) ligand 9], Tnfaip2 (TNF-α-induced protein 2), Anxa5 (annexin A5), and Marcksl1 (myristoylated alanine-rich protein kinase C substrate) in 1 day. The mature M cell marker glycoprotein 2 ( Gp2) was strongly induced by 3 days and expressed by 11% of cells in enteroids. The noncanonical NF-κB pathway was required for RANKL-induced M cell differentiation in enteroids, as addition of RANKL to enteroids from mice with a null mutation in the mitogen-activated protein kinase kinase kinase 14 ( Map3k14) gene encoding NF-κB-inducing kinase failed to induce M cell-associated genes. While the cytokine TNF-α alone had little, if any, effect on expression of M cell-associated genes, addition of TNF-α to RANKL consistently resulted in three- to sixfold higher levels of multiple M cell-associated genes than RANKL alone. One contributing mechanism is the rapid induction by TNF-α of Relb and Nfkb2 (NF-κB subunit 2), genes encoding the two subunits of the noncanonical NF-κB heterodimer. We conclude that endogenous activators of canonical NF-κB signaling present in the gut-associated lymphoid tissue microenvironment, including TNF-α, can play a supportive role in the RANKL-dependent differentiation of M cells in the follicle-associated epithelium." @default.
• W2466671112 created "2016-07-22" @default.
• W2466671112 creator A5007709922 @default.
• W2466671112 creator A5018516417 @default.
• W2466671112 creator A5083102463 @default.
• W2466671112 date "2016-09-01" @default.
• W2466671112 modified "2023-10-15" @default.
• W2466671112 title "TNF-α augments RANKL-dependent intestinal M cell differentiation in enteroid cultures" @default.
• W2466671112 cites W111805191 @default.
• W2466671112 cites W1492189562 @default.
• W2466671112 cites W1519585418 @default.
• W2466671112 cites W1577577364 @default.
• W2466671112 cites W1822745879 @default.
• W2466671112 cites W1965065368 @default.
• W2466671112 cites W1965157206 @default.
• W2466671112 cites W1968291110 @default.
• W2466671112 cites W1975077715 @default.
• W2466671112 cites W1978019581 @default.
• W2466671112 cites W1991586861 @default.
• W2466671112 cites W2001712372 @default.
• W2466671112 cites W2002576510 @default.
• W2466671112 cites W2006699412 @default.
• W2466671112 cites W2009160702 @default.
• W2466671112 cites W2015086458 @default.
• W2466671112 cites W2028799613 @default.
• W2466671112 cites W2028910347 @default.
• W2466671112 cites W2036414872 @default.
• W2466671112 cites W2040711587 @default.
• W2466671112 cites W2041581343 @default.
• W2466671112 cites W2045802581 @default.
• W2466671112 cites W2055258664 @default.
• W2466671112 cites W2059050180 @default.
• W2466671112 cites W2062535359 @default.
• W2466671112 cites W2067589256 @default.
• W2466671112 cites W2069356140 @default.
• W2466671112 cites W2071407489 @default.
• W2466671112 cites W2076980233 @default.
• W2466671112 cites W2085355903 @default.
• W2466671112 cites W2092288031 @default.
• W2466671112 cites W2095076124 @default.
• W2466671112 cites W2107369528 @default.
• W2466671112 cites W2109325879 @default.
• W2466671112 cites W2111341261 @default.
• W2466671112 cites W2116339721 @default.
• W2466671112 cites W2117572085 @default.
• W2466671112 cites W2118567646 @default.
• W2466671112 cites W2120008778 @default.
• W2466671112 cites W2130079153 @default.
• W2466671112 cites W2140648654 @default.
• W2466671112 cites W2144085808 @default.
• W2466671112 cites W2144152742 @default.
• W2466671112 cites W2149206853 @default.
• W2466671112 cites W2152157516 @default.
• W2466671112 cites W2159259228 @default.
• W2466671112 cites W2159722075 @default.
• W2466671112 cites W2159992335 @default.
• W2466671112 cites W2162101019 @default.
• W2466671112 cites W2174345167 @default.
• W2466671112 cites W2195777839 @default.
• W2466671112 cites W2346141601 @default.
• W2466671112 doi "https://doi.org/10.1152/ajpcell.00108.2016" @default.
• W2466671112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5129760" @default.
• W2466671112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27413168" @default.
• W2466671112 hasPublicationYear "2016" @default.
• W2466671112 type Work @default.
• W2466671112 sameAs 2466671112 @default.
• W2466671112 citedByCount "57" @default.
• W2466671112 countsByYear W24666711122016 @default.
• W2466671112 countsByYear W24666711122017 @default.
• W2466671112 countsByYear W24666711122018 @default.
• W2466671112 countsByYear W24666711122019 @default.
• W2466671112 countsByYear W24666711122020 @default.
• W2466671112 countsByYear W24666711122021 @default.
• W2466671112 countsByYear W24666711122022 @default.
• W2466671112 countsByYear W24666711122023 @default.
• W2466671112 crossrefType "journal-article" @default.
• W2466671112 hasAuthorship W2466671112A5007709922 @default.
• W2466671112 hasAuthorship W2466671112A5018516417 @default.
• W2466671112 hasAuthorship W2466671112A5083102463 @default.
• W2466671112 hasBestOaLocation W24666711121 @default.
• W2466671112 hasConcept C104317684 @default.
• W2466671112 hasConcept C148738053 @default.
• W2466671112 hasConcept C153911025 @default.
• W2466671112 hasConcept C170493617 @default.
• W2466671112 hasConcept C184235292 @default.
• W2466671112 hasConcept C2779428903 @default.
• W2466671112 hasConcept C55493867 @default.
• W2466671112 hasConcept C62478195 @default.
• W2466671112 hasConcept C86803240 @default.
• W2466671112 hasConcept C88045685 @default.
• W2466671112 hasConcept C95444343 @default.
• W2466671112 hasConcept C97029542 @default.
• W2466671112 hasConceptScore W2466671112C104317684 @default.
• W2466671112 hasConceptScore W2466671112C148738053 @default.
• W2466671112 hasConceptScore W2466671112C153911025 @default.
• W2466671112 hasConceptScore W2466671112C170493617 @default.
• W2466671112 hasConceptScore W2466671112C184235292 @default.
• W2466671112 hasConceptScore W2466671112C2779428903 @default.

• next