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- W2466706906 abstract "Poly(A)containing RNA was isolated from the polyribosomal and post-ribosomal fractions of the livers of normal and iron-treated rats. These RNA fractions were then translated in a wheat germ system to provide a measure of the amount of ferritin mRNA present in each fraction. Fol- lowing iron administration, there was a 2-fold increase in the amount of ferritin mRNA in the polyribosomal fraction. This increase was not inhibited by prior treatment of the rats with actinomycin D or cordycepin, suggesting a cytoplasmic con- trol mechanism. In normal rats, the post-ribosomal fraction contained an amount of ferritin mRNA equal to that in the polyribosomes. When iron was administered, this untranslat- ed ferritin mRNA became reduced to negligible quantities, thus accounting for the doubling of the ferritin mRNA con- tent of the polyribosomal fraction. A scheme is proposed in which translation of the ferritin mRNA in the post-ribosomal fraction is prevented by adhering ferritin subunits. Iron ad- ministration removes this inhibition of the translation of fer- ritin mRNA by promoting aggregation of these subunits into ferritin." @default.
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- W2466706906 date "2016-01-01" @default.
- W2466706906 modified "2023-09-24" @default.
- W2466706906 title "Novel mechanism for translational control in regulation of ferritin synthesis by iron (liver ferritin mRNA and messenger ribonucleoprotein/response to iron/cordycepin/actinomycin)" @default.
- W2466706906 hasPublicationYear "2016" @default.
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