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• W2466707068 abstract "Nuclear cardiology imaging with SPECT or PET is used widely in North America for the diagnosis and management of patients with coronary artery disease. Conventional myocardial perfusion imaging (MPI) can identify areas of reversible ischemia as suitable targets for coronary artery revascularization by angioplasty or bypass surgery. However, the accuracy of this technique is limited in patients with advanced disease in multiple coronary arteries, where there is no normal reference territory against which to assess the “relative” perfusion defects. We have developed methods for the routine quantification of absolute myocardial blood flow (MBF mL/min/g) and coronary flow reserve (stress/rest MBF) using rubidium-82 dynamic PET imaging. The incremental diagnostic and prognostic value of absolute flow quantification over conventional MPI has been demonstrated in several recent studies. Clinical use of this added information for patient management to direct optimal therapy and the potential to improve cardiac outcomes remains unclear, but may be informed by recent progress and widespread clinical adoption of invasive fractional flow reserve(FFR)-directed revascularization. This paper presents recent progress in this field, toward noninvasive CFR image-guided therapy with cardiac PET and SPECT." @default.
• W2466707068 created "2016-07-22" @default.
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• W2466707068 date "2016-01-01" @default.
• W2466707068 modified "2023-09-25" @default.
• W2466707068 title "Noninvasive PET Flow Reserve Imaging to Direct Optimal Therapies for Myocardial Ischemia" @default.
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• W2466707068 doi "https://doi.org/10.1007/978-4-431-55894-1_12" @default.
• W2466707068 hasPublicationYear "2016" @default.
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