Matches in SemOpenAlex for { <https://semopenalex.org/work/W2466709831> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2466709831 endingPage "65" @default.
- W2466709831 startingPage "1159" @default.
- W2466709831 abstract "Our lab has previously shown that Interleukin (IL)-6- dependent production of autoantibodies against aquaporin 4 in plasmablasts may play a central role in the pathogenesis of neuromyelitis optica (NMO). In this study, we explored the efficacy of tocilizumab, a humanized antibody against IL-6 receptor, in intractable cases of NMO. Eight NMO patients who were unresponsive to current treatments received monthly injections of tocilizumab for at least one year. Tocilizumab significantly reduced the annual relapse rate, neurogenic pain, and fatigue in NMO patients. These results indicate that IL-6 signaling plays a crucial role in the pathogenesis of NMO and highlight the value of IL-6 receptor inhibition for the treatment of NMO." @default.
- W2466709831 created "2016-07-22" @default.
- W2466709831 creator A5028864982 @default.
- W2466709831 creator A5055062205 @default.
- W2466709831 date "2014-10-01" @default.
- W2466709831 modified "2023-10-18" @default.
- W2466709831 title "[Use of tocilizumab, an antibody against interleukin-6 receptor, for the treatment of neuromyelitis optica]." @default.
- W2466709831 doi "https://doi.org/10.11477/mf.1416200004" @default.
- W2466709831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25296870" @default.
- W2466709831 hasPublicationYear "2014" @default.
- W2466709831 type Work @default.
- W2466709831 sameAs 2466709831 @default.
- W2466709831 citedByCount "2" @default.
- W2466709831 countsByYear W24667098312019 @default.
- W2466709831 countsByYear W24667098312023 @default.
- W2466709831 crossrefType "journal-article" @default.
- W2466709831 hasAuthorship W2466709831A5028864982 @default.
- W2466709831 hasAuthorship W2466709831A5055062205 @default.
- W2466709831 hasConcept C11988809 @default.
- W2466709831 hasConcept C126322002 @default.
- W2466709831 hasConcept C159654299 @default.
- W2466709831 hasConcept C163764329 @default.
- W2466709831 hasConcept C170493617 @default.
- W2466709831 hasConcept C200155923 @default.
- W2466709831 hasConcept C203014093 @default.
- W2466709831 hasConcept C2777178219 @default.
- W2466709831 hasConcept C2777575956 @default.
- W2466709831 hasConcept C2778690821 @default.
- W2466709831 hasConcept C2780942790 @default.
- W2466709831 hasConcept C2781137167 @default.
- W2466709831 hasConcept C71924100 @default.
- W2466709831 hasConcept C74172505 @default.
- W2466709831 hasConceptScore W2466709831C11988809 @default.
- W2466709831 hasConceptScore W2466709831C126322002 @default.
- W2466709831 hasConceptScore W2466709831C159654299 @default.
- W2466709831 hasConceptScore W2466709831C163764329 @default.
- W2466709831 hasConceptScore W2466709831C170493617 @default.
- W2466709831 hasConceptScore W2466709831C200155923 @default.
- W2466709831 hasConceptScore W2466709831C203014093 @default.
- W2466709831 hasConceptScore W2466709831C2777178219 @default.
- W2466709831 hasConceptScore W2466709831C2777575956 @default.
- W2466709831 hasConceptScore W2466709831C2778690821 @default.
- W2466709831 hasConceptScore W2466709831C2780942790 @default.
- W2466709831 hasConceptScore W2466709831C2781137167 @default.
- W2466709831 hasConceptScore W2466709831C71924100 @default.
- W2466709831 hasConceptScore W2466709831C74172505 @default.
- W2466709831 hasIssue "10" @default.
- W2466709831 hasLocation W24667098311 @default.
- W2466709831 hasOpenAccess W2466709831 @default.
- W2466709831 hasPrimaryLocation W24667098311 @default.
- W2466709831 hasRelatedWork W2064656238 @default.
- W2466709831 hasRelatedWork W2085486259 @default.
- W2466709831 hasRelatedWork W2114747096 @default.
- W2466709831 hasRelatedWork W2182323848 @default.
- W2466709831 hasRelatedWork W2355352419 @default.
- W2466709831 hasRelatedWork W2466709831 @default.
- W2466709831 hasRelatedWork W2504468886 @default.
- W2466709831 hasRelatedWork W2904631220 @default.
- W2466709831 hasRelatedWork W2984193153 @default.
- W2466709831 hasRelatedWork W4285797907 @default.
- W2466709831 hasVolume "66" @default.
- W2466709831 isParatext "false" @default.
- W2466709831 isRetracted "false" @default.
- W2466709831 magId "2466709831" @default.
- W2466709831 workType "article" @default.