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• W2466734630 endingPage "1059" @default.
• W2466734630 startingPage "1059" @default.
• W2466734630 abstract "Zinc is an essential metal to life. This transition metal is a structural component of many proteins and is actively involved in the catalytic activity of cell enzymes. In either case, these zinc-containing proteins are metalloproteins. However, the amino acid residues that serve as ligands for metal coordination are not necessarily the same in structural proteins compared to enzymes. While crystals of structural proteins that bind zinc reveal a higher preference for cysteine sulfhydryls rather than histidine imidazole rings, catalytic enzymes reveal the opposite, i.e., a greater preference for the histidines over cysteines for catalysis, plus the influence of carboxylic acids. Based on this paradigm, we reviewed the putative ligands of zinc in ionotropic receptors, where zinc has been described as an allosteric modulator of channel receptors. Although these receptors do not strictly qualify as metalloproteins since they do not normally bind zinc in structural domains, they do transitorily bind zinc at allosteric sites, modifying transiently the receptor channel’s ion permeability. The present contribution summarizes current information showing that zinc allosteric modulation of receptor channels occurs by the preferential metal coordination to imidazole rings as well as to the sulfhydryl groups of cysteine in addition to the carboxyl group of acid residues, as with enzymes and catalysis. It is remarkable that most channels, either voltage-sensitive or transmitter-gated receptor channels, are susceptible to zinc modulation either as positive or negative regulators." @default.
• W2466734630 created "2016-07-22" @default.
• W2466734630 creator A5019900607 @default.
• W2466734630 creator A5038851986 @default.
• W2466734630 date "2016-07-02" @default.
• W2466734630 modified "2023-09-25" @default.
• W2466734630 title "Zinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as Metalloproteins" @default.
• W2466734630 cites W1520935000 @default.
• W2466734630 cites W1524529043 @default.
• W2466734630 cites W1536892476 @default.
• W2466734630 cites W1540396301 @default.
• W2466734630 cites W1552886287 @default.
• W2466734630 cites W1561410732 @default.
• W2466734630 cites W1568502048 @default.
• W2466734630 cites W1591734024 @default.
• W2466734630 cites W1606994795 @default.
• W2466734630 cites W1612987016 @default.
• W2466734630 cites W1756214999 @default.
• W2466734630 cites W1871656259 @default.
• W2466734630 cites W1882262859 @default.
• W2466734630 cites W1917503746 @default.
• W2466734630 cites W1926752139 @default.
• W2466734630 cites W1958431711 @default.
• W2466734630 cites W1967123623 @default.
• W2466734630 cites W1967194113 @default.
• W2466734630 cites W1967225412 @default.
• W2466734630 cites W1967428972 @default.
• W2466734630 cites W1967476518 @default.
• W2466734630 cites W1973365348 @default.
• W2466734630 cites W1976108852 @default.
• W2466734630 cites W1977584840 @default.
• W2466734630 cites W1977760597 @default.
• W2466734630 cites W1979100273 @default.
• W2466734630 cites W1982189276 @default.
• W2466734630 cites W1982635657 @default.
• W2466734630 cites W1983523125 @default.
• W2466734630 cites W1984113160 @default.
• W2466734630 cites W1986171863 @default.
• W2466734630 cites W1989257844 @default.
• W2466734630 cites W1995233280 @default.
• W2466734630 cites W1995271633 @default.
• W2466734630 cites W1995332367 @default.
• W2466734630 cites W1997865085 @default.
• W2466734630 cites W1998093640 @default.
• W2466734630 cites W1998697859 @default.
• W2466734630 cites W2002791084 @default.
• W2466734630 cites W2004306690 @default.
• W2466734630 cites W2006544095 @default.
• W2466734630 cites W2008259235 @default.
• W2466734630 cites W2008603008 @default.
• W2466734630 cites W2009664257 @default.
• W2466734630 cites W2012671084 @default.
• W2466734630 cites W2021701700 @default.
• W2466734630 cites W2022397228 @default.
• W2466734630 cites W2024463427 @default.
• W2466734630 cites W2030131290 @default.
• W2466734630 cites W2030344669 @default.
• W2466734630 cites W2032232947 @default.
• W2466734630 cites W2035011876 @default.
• W2466734630 cites W2035089473 @default.
• W2466734630 cites W2035192222 @default.
• W2466734630 cites W2038937950 @default.
• W2466734630 cites W2043954762 @default.
• W2466734630 cites W2043986265 @default.
• W2466734630 cites W2046394738 @default.
• W2466734630 cites W2047426956 @default.
• W2466734630 cites W2050643839 @default.
• W2466734630 cites W2052458078 @default.
• W2466734630 cites W2052509491 @default.
• W2466734630 cites W2054049929 @default.
• W2466734630 cites W2054827104 @default.
• W2466734630 cites W2056917649 @default.
• W2466734630 cites W2059077175 @default.
• W2466734630 cites W2059267634 @default.
• W2466734630 cites W2061044370 @default.
• W2466734630 cites W2061136398 @default.
• W2466734630 cites W2063034379 @default.
• W2466734630 cites W2063579854 @default.
• W2466734630 cites W2064222655 @default.
• W2466734630 cites W2064529873 @default.
• W2466734630 cites W2064636251 @default.
• W2466734630 cites W2066662117 @default.
• W2466734630 cites W2066697047 @default.
• W2466734630 cites W2067340918 @default.
• W2466734630 cites W2071201135 @default.
• W2466734630 cites W2072094633 @default.
• W2466734630 cites W2073253858 @default.
• W2466734630 cites W2073733489 @default.
• W2466734630 cites W2077382515 @default.
• W2466734630 cites W2081155886 @default.
• W2466734630 cites W2082439356 @default.
• W2466734630 cites W2086487208 @default.
• W2466734630 cites W2088252951 @default.
• W2466734630 cites W2091591161 @default.
• W2466734630 cites W2092542394 @default.
• W2466734630 cites W2092686460 @default.
• W2466734630 cites W2092742664 @default.
• W2466734630 cites W2094526443 @default.

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