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- W2466753453 abstract "To determine if embryos can modulate steroid hormone production by luteinized granulosa cells.Granulosa cells obtained from follicular aspirates were cultured alone or in the presence of a two-pronuclear zygote. The production of E2 and P by these cultures was evaluated by RIA.In Vitro Fertilization Unit in an academic research environment.Sixteen women undergoing IVF.Standard IVF-ET treatment cycle using leuprolide acetate for pituitary desensitization before hMG or urofollitropin for ovarian stimulation.Estradiol and P concentration in culture media of luteinized granulosa cells alone or granulosa cells cocultured with a two-pronuclear embryo.Both E2 and P production by luteinized granulosa cells was reduced when cultured in the presence of an embryo.Human embryos secrete a factor that regulates granulosa cell steroidogenesis." @default.
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- W2466753453 date "1996-09-01" @default.
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- W2466753453 title "Autologous granulosa cell coculture demonstrates zygote suppression of granulosa cell steroidogenesis" @default.
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- W2466753453 doi "https://doi.org/10.1016/s0015-0282(16)58513-6" @default.
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