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- W2466809802 abstract "Human papillomaviruses induce benign or malignant epithelial proliferations in both skin or mucosa and are involved in the development of anogenital cancer. One can consider two approaches towards vaccine development: prevention of infection by prophylactic induction of virus neutralizing antibodies or therapeutic vaccination which would lead to regression of already existing lesions. Neutralizing antibodies are directed against 3-dimensional structures on intact virions. Such antibodies which are protective in model systems can be induced safely by DNA-free virus-like-particles. These constructs are candidates for a prophylactic vaccine. A further approach to optimize the vaccination strategy concentrates on immunotherapy of precancerous or malignant lesions by induction of a specific cell-mediated immune response. Hypothetically the transforming papillomavirus proteins which are expressed in basal layers of the epidermis could be used as a therapeutic vaccine in the form of synthetic peptides." @default.
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- W2466809802 date "1996-10-01" @default.
- W2466809802 modified "2023-09-25" @default.
- W2466809802 title "Immunologische Aspekte bei Infektionen mit Papillomviren Aussichten auf einen Impfstoff" @default.
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- W2466809802 doi "https://doi.org/10.1007/s001050050500" @default.
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