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• W2466900317 abstract "Plasma membrane Ca2+-ATPase (PMCA) plays a vital role in maintaining cytosolic calcium concentration ([Ca2+]i). Given that many diseases have modified PMCA expression and activity, PMCA is an important potential target for therapeutic treatment. This study demonstrates that the non-toxic, naturally-occurring polyphenol resveratrol (RES) induces increases in [Ca2+]i via PMCA inhibition in primary dermal fibroblasts and MDA-MB-231 breast cancer cells. Our results also illustrate that RES and the fluorescent intracellular calcium indicator Fura-2, are compatible for simultaneous use, in contrast to previous studies, which indicated that RES modulates the Fura-2 fluorescence independent of calcium concentration. Because RES has been identified as a PMCA inhibitor, further studies may be conducted to develop more specific PMCA inhibitors from RES derivatives for potential therapeutic use." @default.
• W2466900317 created "2016-07-22" @default.
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• W2466900317 date "2016-09-01" @default.
• W2466900317 modified "2023-10-18" @default.
• W2466900317 title "Resveratrol inhibits plasma membrane Ca 2+ -ATPase inducing an increase in cytoplasmic calcium" @default.
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• W2466900317 doi "https://doi.org/10.1016/j.bbrep.2016.06.019" @default.
• W2466900317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5613515" @default.
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