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- W2466928150 abstract "INTRODUCTION Celiac disease (CD) diagnosis can be improved if a scoring system comprising clinical, nutritional, serological and histopathological elements is applied. DQβ1*02 and/ or DQβ1*0302 alleles can be expected to be more frequent among subjects with the highest scores. OBJECTIVES To assess the relationship between score assigned to the patient by means of the system developed and alleles associated with CD. METHODS Scores were assigned to 69 patients (Women: 68.1%; Ages ≤ 60 years: 95.7%) assisted by a multidisciplinary group for management of CD, using an updated version of a previously described score system (CeliacScore 2.0) were correlated with the occurrence of DQβ1*02 and/or DQβ1*0302 alleles. CD was diagnosed if the assigned score was ≥ 10. RESULTS 17.4% of studied patients were diagnosed as CD. DQβ1*02 and/or DQβ1*0302 alleles were present in 56.5% of our cases. Scores assigned to patient's were independent of the presence of alleles of interest (c² = 2.3; p > 0.319). 75.0% of subjects with a score higher than 10 had the alleles of interest. The probability for the presence of DQβ1*02 and/or DQβ1*0302 alleles was 2.7 in patients with scores ≥ 10. CONCLUSIONS The described system can be useful in the CD diagnosis. Alleles associated with CD concentrated among those with the highest scores. Scoring system's operating characteristics should be explored in further studies." @default.
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- W2466928150 date "2011-01-01" @default.
- W2466928150 modified "2023-10-01" @default.
- W2466928150 title "[CeliacScore 2.0: Up to date of the Score System for the Diagnosis of Celiac Disease: association with DQβ1*02 and DQβ1*0302 alleles]." @default.
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