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- W2466994599 abstract "Acinetobacter baumannii is a Gram-negative bacillus found in many hospital environments and its very high resistance toantimicrobial renders it as a successful nosocomial pathogen. There are many reports of Multi Drug Resistant A. baumanniifrom hospitals all over the world. ESBLs are beta-lactamases that hydrolyze extended-spectrum cephalosporins with anoxyimino side chain; These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime. The ESBLs are frequently plasmidencoded. Plasmids responsible for ESBL production frequently carry genes encoding resistance to other drug classes (forexample, aminoglycosides). Therefore, antibiotic options in the treatment of ESBL-producing organisms are extremely limited.This study aimed to assess the incidence of ESBLs in 48 burn isolates of A. baumannii. The susceptibilities of isolates todifferent antibiotics were tested by the Kirby-Bauer method. The Minimum inhibitory concentration of cefotaxime for each isolatewas determined by Hicomb strips in the range of 0.001-240 μg of antibiotic. For phenotypic detection of the ESBLs double discdiffusion method. Cefazolin (100%), ciprofloxacin (100%) ofloxacin (95.8%) and kanamycin (95.8%) showed the highest rate ofresistance and amikacin (52%) and imipenem (14.6%) demonstrated the lowest. 45.8% of isolates showed resistance to the 11tested antimicrobials. 46 isolates (95.8%) were resistant to all tested concentrations of Cefotaxime (The Minimum inhibitoryconcentrations were above 240 μg). only one isolate (2%) has been considered as ESBL producing isolate. The high resistanceof isolates to cefotaxime, ceftazidime and cefepime in companion with the low number of ESBL producing isolates, proposedanother resistance mechanisms for these isolates to extended-spectrum cephalosporins." @default.
- W2466994599 created "2016-07-22" @default.
- W2466994599 date "2011-01-01" @default.
- W2466994599 modified "2023-09-24" @default.
- W2466994599 title "The Prevalence Of Extended Spectrum Beta-lactamases In Acinetobacter baumannii Isolates From Burn Wounds In Iran" @default.
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- W2466994599 doi "https://doi.org/10.5580/1f87" @default.
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