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- W2467016816 abstract "Chronic kidney disease (CKD) is an increasing and global health problem with a great economic burden for healthcare system. Therefore to slow down the progression of this condition is a main objective in nephrology. It has been extensively reported that microinflammation, immune system deregulation, and oxidative stress contribute to CKD progression. Additionally, dialysis worsens this clinical condition because of the contact of blood with bioincompatible dialytic devices. Numerous studies have shown the close link between immune system impairment and CKD but most have been performed using classical biomolecular strategies. These methodologies are limited in their ability to discover new elements and enable measuring the simultaneous influence of multiple factors. The “omics” techniques could overcome these gaps. For example, transcriptomics has revealed that mitochondria and inflammasome have a role in pathogenesis of CKD and are pivotal elements in the cellular alterations leading to systemic complications. We believe that a larger employment of this technique, together with other “omics” methodologies, could help clinicians to obtain new pathogenetic insights, novel diagnostic biomarkers, and therapeutic targets. Finally, transcriptomics could allow clinicians to personalize therapeutic strategies according to individual genetic background (nutrigenomic and pharmacogenomic). In this review, we analyzed the available transcriptomic studies involving CKD patients." @default.
- W2467016816 created "2016-07-22" @default.
- W2467016816 creator A5008310339 @default.
- W2467016816 creator A5056233798 @default.
- W2467016816 creator A5065956126 @default.
- W2467016816 creator A5080234825 @default.
- W2467016816 creator A5085555560 @default.
- W2467016816 date "2016-01-01" @default.
- W2467016816 modified "2023-10-14" @default.
- W2467016816 title "Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease" @default.
- W2467016816 cites W1506551612 @default.
- W2467016816 cites W1529674879 @default.
- W2467016816 cites W1536773986 @default.
- W2467016816 cites W1563090311 @default.
- W2467016816 cites W1575233708 @default.
- W2467016816 cites W159470044 @default.
- W2467016816 cites W1595582953 @default.
- W2467016816 cites W1602088950 @default.
- W2467016816 cites W1605185105 @default.
- W2467016816 cites W1684971175 @default.
- W2467016816 cites W1756750202 @default.
- W2467016816 cites W1787685519 @default.
- W2467016816 cites W1816419079 @default.
- W2467016816 cites W1824574575 @default.
- W2467016816 cites W1965383347 @default.
- W2467016816 cites W1965780550 @default.
- W2467016816 cites W1971715564 @default.
- W2467016816 cites W1974559428 @default.
- W2467016816 cites W1975768263 @default.
- W2467016816 cites W1977472135 @default.
- W2467016816 cites W1979345265 @default.
- W2467016816 cites W1979722818 @default.
- W2467016816 cites W1980197219 @default.
- W2467016816 cites W1980872444 @default.
- W2467016816 cites W1980995990 @default.
- W2467016816 cites W1983899279 @default.
- W2467016816 cites W1987073410 @default.
- W2467016816 cites W1987308393 @default.
- W2467016816 cites W1987524865 @default.
- W2467016816 cites W1993566636 @default.
- W2467016816 cites W1993672576 @default.
- W2467016816 cites W1993753754 @default.
- W2467016816 cites W1995910069 @default.
- W2467016816 cites W1996978408 @default.
- W2467016816 cites W2000204073 @default.
- W2467016816 cites W2001157494 @default.
- W2467016816 cites W2004744807 @default.
- W2467016816 cites W2007639122 @default.
- W2467016816 cites W2009004909 @default.
- W2467016816 cites W2009567157 @default.
- W2467016816 cites W2009572885 @default.
- W2467016816 cites W2009641895 @default.
- W2467016816 cites W2010314193 @default.
- W2467016816 cites W2011674123 @default.
- W2467016816 cites W2013169717 @default.
- W2467016816 cites W2014054401 @default.
- W2467016816 cites W2014100516 @default.
- W2467016816 cites W2017933369 @default.
- W2467016816 cites W2018901137 @default.
- W2467016816 cites W2019964412 @default.
- W2467016816 cites W2021013141 @default.
- W2467016816 cites W2021125816 @default.
- W2467016816 cites W2023558395 @default.
- W2467016816 cites W2025416121 @default.
- W2467016816 cites W2027722722 @default.
- W2467016816 cites W2028773046 @default.
- W2467016816 cites W2032576629 @default.
- W2467016816 cites W2033808144 @default.
- W2467016816 cites W2036127346 @default.
- W2467016816 cites W2038713498 @default.
- W2467016816 cites W2039125940 @default.
- W2467016816 cites W2040137092 @default.
- W2467016816 cites W2041083337 @default.
- W2467016816 cites W2044773944 @default.
- W2467016816 cites W2046872149 @default.
- W2467016816 cites W2049228689 @default.
- W2467016816 cites W2050081397 @default.
- W2467016816 cites W2053373031 @default.
- W2467016816 cites W2055003420 @default.
- W2467016816 cites W2055573732 @default.
- W2467016816 cites W2056056517 @default.
- W2467016816 cites W2056499600 @default.
- W2467016816 cites W2056976690 @default.
- W2467016816 cites W2059873008 @default.
- W2467016816 cites W2060457268 @default.
- W2467016816 cites W2060842569 @default.
- W2467016816 cites W2061205710 @default.
- W2467016816 cites W2063649030 @default.
- W2467016816 cites W2066717161 @default.
- W2467016816 cites W2067366577 @default.
- W2467016816 cites W2067601714 @default.
- W2467016816 cites W2069322489 @default.
- W2467016816 cites W2072617228 @default.
- W2467016816 cites W2074146482 @default.
- W2467016816 cites W2080523332 @default.
- W2467016816 cites W2081730949 @default.
- W2467016816 cites W2083306286 @default.
- W2467016816 cites W2088309797 @default.