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• W2467038351 abstract "The Parma group study, a randomized multicenter trial of treatment for patients with chemotherapy-responsive, relapsed aggressive non-Hodgkin’s lymphoma, has established the superiority of high-dose chemotherapy and autologous stem cell transplant over conventional salvage chemotherapy [1]. Subsequently, autologous stem cell transplant has become a standard approach for relapsed non-Hodgkin’s lymphoma. Recent reports also have revealed that high-dose chemotherapy followed by autologous stem cell transplant is superior to standard chemotherapy as a primary treatment for newly diagnosed patients with aggressive non-Hodgkin’s lymphoma [2, 3]. In our institution and the affiliated hospitals, the so-called Fukuoka Blood and Marrow Transplantation Group (upfront high-dose chemotherapy with autologous peripheral blood stem cell transplant after six cycles of the standard CHOP regimen) has been provided as consolidation for newly diagnosed patients as well as relapsed patients with aggressive non-Hodgkin’s lymphoma since 1990 [4]. The specific disease entities that we consider are aggressive B-cell lymphomas, such as diffuse, large B-cell lymphoma and peripheral T-cell lymphomas, at the stage of high intermediate to high risk, according to the International Prognostic Index. The conditioning regimen consists of MCEC (ranimustine 200 mg/m2 × 2, carboplatin 300 mg/m2 × 4, etoposide 500 mg/m2 × 3, cyclophosphamide 50 mg/kg × 2). In total, 3.6 % of patients died of transplant-related causes. The estimated overall survival at 5 years following autologous stem cell transplant was 63 % in aggressive B-cell lymphomas (n = 252) and 62 % in peripheral T-cell lymphomas (n = 39) in the Fukuoka Blood and Marrow Transplantation Group experience. Five-year overall survival was significantly higher in patients transplanted at the first complete remission than in those with other disease status (79 % vs. 50 % in diffuse, large B-cell lymphoma and 83 % vs. 49 % in peripheral T-cell lymphomas, respectively)." @default.
• W2467038351 created "2016-07-22" @default.
• W2467038351 creator A5066039877 @default.
• W2467038351 date "2012-12-20" @default.
• W2467038351 modified "2023-09-24" @default.
• W2467038351 title "Lymphoma (Following Autologous Stem Cell Transplant) Surveillance Counterpoint: Japan" @default.
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• W2467038351 doi "https://doi.org/10.1007/978-1-60327-969-7_94" @default.
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