FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467091785> ?p ?o ?g. }

• W2467091785 endingPage "8187" @default.
• W2467091785 startingPage "8182" @default.
• W2467091785 abstract "Insulin increases lipid synthesis in liver by activating transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c). SREBP-1c activates the transcription of all genes necessary for fatty acid synthesis. Insulin induction of SREBP-1c requires LXRα, a nuclear receptor. Transcription of SREBP-1c also requires transcription factor C/EBPβ, but a connection between LXRα and C/EBPβ has not been made. Here we show that LXRα and C/EBPβ form a complex that can be immunoprecipitated from rat liver nuclei. Chromatin immunoprecipitation assays showed that the LXRα-C/EBPβ complex binds to the SREBP-1c promoter in a region that contains two binding sites for LXRα and is known to be required for insulin induction. Knockdown of C/EBPβ in fresh rat hepatocytes or mouse livers in vivo reduces the ability of insulin to increase SREBP-1c mRNA. The LXRα-C/EBPβ complex is bound to the SREBP-1c promoter in the absence or presence of insulin, indicating that insulin acts not by increasing the formation of this complex, but rather by activating it." @default.
• W2467091785 created "2016-07-22" @default.
• W2467091785 creator A5058164552 @default.
• W2467091785 creator A5065607890 @default.
• W2467091785 creator A5079762911 @default.
• W2467091785 date "2016-07-05" @default.
• W2467091785 modified "2023-10-16" @default.
• W2467091785 title "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex" @default.
• W2467091785 cites W1975189993 @default.
• W2467091785 cites W1979582511 @default.
• W2467091785 cites W1994173047 @default.
• W2467091785 cites W2005393972 @default.
• W2467091785 cites W2016126865 @default.
• W2467091785 cites W2020970433 @default.
• W2467091785 cites W2024851295 @default.
• W2467091785 cites W2030610610 @default.
• W2467091785 cites W2039252539 @default.
• W2467091785 cites W2061864595 @default.
• W2467091785 cites W2072482644 @default.
• W2467091785 cites W2081832076 @default.
• W2467091785 cites W2088436733 @default.
• W2467091785 cites W2093296161 @default.
• W2467091785 cites W2112632255 @default.
• W2467091785 cites W2129011493 @default.
• W2467091785 cites W2129346720 @default.
• W2467091785 cites W2134292324 @default.
• W2467091785 cites W2140439419 @default.
• W2467091785 cites W2146544786 @default.
• W2467091785 cites W2153673003 @default.
• W2467091785 cites W2171302838 @default.
• W2467091785 cites W2399469784 @default.
• W2467091785 cites W274997347 @default.
• W2467091785 cites W4252021281 @default.
• W2467091785 doi "https://doi.org/10.1073/pnas.1608987113" @default.
• W2467091785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4961151" @default.
• W2467091785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27382175" @default.
• W2467091785 hasPublicationYear "2016" @default.
• W2467091785 type Work @default.
• W2467091785 sameAs 2467091785 @default.
• W2467091785 citedByCount "51" @default.
• W2467091785 countsByYear W24670917852017 @default.
• W2467091785 countsByYear W24670917852018 @default.
• W2467091785 countsByYear W24670917852019 @default.
• W2467091785 countsByYear W24670917852020 @default.
• W2467091785 countsByYear W24670917852021 @default.
• W2467091785 countsByYear W24670917852022 @default.
• W2467091785 countsByYear W24670917852023 @default.
• W2467091785 crossrefType "journal-article" @default.
• W2467091785 hasAuthorship W2467091785A5058164552 @default.
• W2467091785 hasAuthorship W2467091785A5065607890 @default.
• W2467091785 hasAuthorship W2467091785A5079762911 @default.
• W2467091785 hasBestOaLocation W24670917851 @default.
• W2467091785 hasConcept C101762097 @default.
• W2467091785 hasConcept C104317684 @default.
• W2467091785 hasConcept C132376346 @default.
• W2467091785 hasConcept C134320426 @default.
• W2467091785 hasConcept C149240914 @default.
• W2467091785 hasConcept C150194340 @default.
• W2467091785 hasConcept C153911025 @default.
• W2467091785 hasConcept C167400880 @default.
• W2467091785 hasConcept C173396325 @default.
• W2467091785 hasConcept C185592680 @default.
• W2467091785 hasConcept C29512474 @default.
• W2467091785 hasConcept C55493867 @default.
• W2467091785 hasConcept C63932345 @default.
• W2467091785 hasConcept C85051948 @default.
• W2467091785 hasConcept C86339819 @default.
• W2467091785 hasConcept C86803240 @default.
• W2467091785 hasConcept C95444343 @default.
• W2467091785 hasConceptScore W2467091785C101762097 @default.
• W2467091785 hasConceptScore W2467091785C104317684 @default.
• W2467091785 hasConceptScore W2467091785C132376346 @default.
• W2467091785 hasConceptScore W2467091785C134320426 @default.
• W2467091785 hasConceptScore W2467091785C149240914 @default.
• W2467091785 hasConceptScore W2467091785C150194340 @default.
• W2467091785 hasConceptScore W2467091785C153911025 @default.
• W2467091785 hasConceptScore W2467091785C167400880 @default.
• W2467091785 hasConceptScore W2467091785C173396325 @default.
• W2467091785 hasConceptScore W2467091785C185592680 @default.
• W2467091785 hasConceptScore W2467091785C29512474 @default.
• W2467091785 hasConceptScore W2467091785C55493867 @default.
• W2467091785 hasConceptScore W2467091785C63932345 @default.
• W2467091785 hasConceptScore W2467091785C85051948 @default.
• W2467091785 hasConceptScore W2467091785C86339819 @default.
• W2467091785 hasConceptScore W2467091785C86803240 @default.
• W2467091785 hasConceptScore W2467091785C95444343 @default.
• W2467091785 hasFunder F4320306226 @default.
• W2467091785 hasFunder F4320332161 @default.
• W2467091785 hasIssue "29" @default.
• W2467091785 hasLocation W24670917851 @default.
• W2467091785 hasLocation W24670917852 @default.
• W2467091785 hasLocation W24670917853 @default.
• W2467091785 hasLocation W24670917854 @default.
• W2467091785 hasOpenAccess W2467091785 @default.
• W2467091785 hasPrimaryLocation W24670917851 @default.
• W2467091785 hasRelatedWork W2000592725 @default.
• W2467091785 hasRelatedWork W2006611449 @default.
• W2467091785 hasRelatedWork W2024851295 @default.

• next