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• W2467133095 abstract "Neuron-specific enolase (NSE) concentrations are prognostic following traumatic and anoxic brain injury and may provide a method to quantify neuronal injury in other populations. We determined the association of admission plasma NSE concentrations with mortality and delirium in critically ill septic patients.We performed a retrospective analysis of 124 patients from a larger sepsis cohort. Plasma NSE was measured in the earliest blood draw at intensive care unit admission. Primary outcomes were 30-day mortality and intensive care unit delirium determined by chart review.Sixty-one patients (49.2%) died within 30 days, and delirium developed in 34 (31.5%) of the 108 patients who survived at least 24 hours and were not persistently comatose. Each doubling of the NSE concentration was associated with a 7.3% (95% confidence interval [CI] 2.5-12.0, P= .003) increased risk of 30-day mortality and a 5.2% (95% CI 3.2-7.2, P< .001) increased risk of delirium. An NSE concentration >12.5 μg/L was independently associated with a 23.3% (95% CI 6.7-39.9, P= .006) increased risk of 30-day mortality and a 29.3% (95% CI 8.8-49.8, P= .005) increased risk of delirium.Higher plasma NSE concentrations were associated with mortality and delirium in critically ill septic patients, suggesting that NSE may have utility as a marker of neuronal injury in sepsis." @default.
• W2467133095 created "2016-07-22" @default.
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• W2467133095 date "2016-12-01" @default.
• W2467133095 modified "2023-10-15" @default.
• W2467133095 title "Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis" @default.
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• W2467133095 doi "https://doi.org/10.1016/j.jcrc.2016.06.012" @default.
• W2467133095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5096992" @default.
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