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• W2467153308 abstract "PURPOSE: Strenuous endurance exercise stimulates transient cardiac perturbations with ambiguous health outcomes. Therefore, this study aimed to alter the magnitude and time-course of exercise-induced functional and biochemical cardiac perturbations by manipulating the exercise intensity-duration matrix. METHODS: Echocardiograph-derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and serum high-sensitivity cardiac troponin (hs-cTnI) concentration, were examined in 10 males (Age: 27 ± 4 yr; VO2peak: 4.0 ± 0.8L•min-1) before, throughout (50-, 75- & 100-%), and during recovery (1-, 3-, 6- & 24-h) from two exercise trials. The two exercise trials consisted of cycling for either 90-min above, or 120-min within, the moderate-intensity exercise domain to complete an equivalent total mechanical work. RESULTS: LVGLS decreased (p&lt0.01) during the 90-min trial only, with reductions peaking at 1-h post (pre: -19.9 ± 0.6; 1-h post: -18.5 ± 0.7%) and persisting for >24-h into recovery. RVGLS decreased (p&lt0.05) during both exercise trials with reductions in the 90-min trial peaking at 1-h post (pre: -27.5 ± 0.7%; 1-h post: -25.1 ± 0.8%) and persisting for >24-h into recovery. Serum hs-cTnI increased (p&lt0.01) during both exercise trials with concentrations peaking at 3-h post, but only exceeding cardio-healthy reference limits (14ng/L) in the 90-min trial (pre: 4.2 ± 2.4ng/L; 3-h post: 25.1 ± 7.9ng/L). CONCLUSIONS: Exercise-induced reductions in ventricular strain and increases in cardiac injury markers persist for 24 hours following exercise that is typical of day-to-day endurance exercise training; however, the magnitude and time-course of this response can be altered by manipulating the intensity-duration matrix." @default.
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• W2467153308 date "2016-05-01" @default.
• W2467153308 modified "2023-09-26" @default.
• W2467153308 title "Manipulating The Exercise Intensity-duration Matrix Has A Profound Impact On Exercise-induced Functional And Biochemical Perturbations In The Human Heart." @default.
• W2467153308 doi "https://doi.org/10.1249/01.mss.0000487396.08615.d0" @default.
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