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• W2467153410 abstract "In this paper we numerically simulate the phenomenon of bone growth in bone defects as driven by external mechanical excitation. Bone growth is accounted for through a continuum model that allows simulation of the filling of a defect. The influence of the model boundary conditions is also discussed. Two and three dimensional simulations are presented, explicitly showing the bone regeneration process inside the cavity on a weekly basis. Numerical results are qualitatively compared with literature experimental data from a rat calvarial defect exposed to low-intensity pulsed ultrasound. The obtained results show trend correlations with the targeted phenomenological observations and allow us to perform a first evaluation of the proposed model parameters to be optimized for clinically relevant situations, even if a systematic experimental campaign is still needed to precisely identify the bio-mechanical parameters involved." @default.
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• W2467153410 date "2016-06-21" @default.
• W2467153410 modified "2023-10-18" @default.
• W2467153410 title "Mechanically-driven bone remodeling simulation: Application to LIPUS treated rat calvarial defects" @default.
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• W2467153410 doi "https://doi.org/10.1177/1081286516651473" @default.
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