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• W2467181010 abstract "// Le-chi Ye 1, 2 , Tao Chen 1 , De-xiang Zhu 1 , Shi-xu Lv 1 , Jun-jun Qiu 3 , Jianmin Xu 1 , Feng-Lai Yuan 4, * , Ye Wei 1, * 1 Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, P.R. China 2 Department of Oncological Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P.R. China 3 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China 4 The Third Hospital Affiliated to Nantong University, Nantong, P.R. China * These authors contributed equally to this work Correspondence to: Ye Wei, email: 13818661815@126.com Feng-Lai Yuan, email: bjjq88@163.com Keywords: colorectal cancer, long non-coding RNA, lncRNA-CLMAT3, cell cycle pathway Received: March 17, 2016      Accepted: May 29, 2016      Published: July 06, 2016 ABSTRACT Over-expression of long non-coding RNA (lncRNA)-CLMAT3 is significantly associated with colorectal liver metastasis and is an independent predictor of poor survival for colorectal cancer patients. However, as little is known regarding the role of this gene in the proliferation of colorectal cancer in vitro , we investigated the involvement of lncRNA-CLMAT3 in colorectal cancer cell proliferation. In this study, we demonstrate that lncRNA-CLMAT3 expression was significantly increased in colorectal cancer cells compared with a normal intestinal mucous cell line and that inhibition of lncRNA-CLMAT3 suppressed colorectal cancer cell proliferation in vitro . We also found that this reduced colorectal cancer cell proliferation due to lncRNA-CLMAT3 knockdown is associated with G0/G1 cell-cycle arrest induction and apoptosis enhancement. Furthermore, lncRNA-CLMAT3 knockdown enhanced Cdh1 expression and resulted in p27Kip accumulation via increased Skp2 protein ubiquitination. Taken together, our findings suggest that reducing lncRNA-CLMAT3 inhibits colorectal cancer cell proliferation by affecting cell cycle components." @default.
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• W2467181010 date "2016-07-06" @default.
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• W2467181010 title "Downregulated long non-coding RNA CLMAT3 promotes the proliferation of colorectal cancer cells by targeting regulators of the cell cycle pathway" @default.
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• W2467181010 doi "https://doi.org/10.18632/oncotarget.10431" @default.
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