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- W2467228907 abstract "Objective: To analyze the spinal cord morphology in patients with chronic traumatic paraplegia at the thoracic level, for a possible inclusion in trials of cell therapy. Material and method: We reviewed Magnetic Resonance (MR) studies in 100 patients with a traumatic thoracic paraplegia (ASIA A). Results: In 14% of cases, the presence of artifacts prevented the study. 30% showed large vertebral kyphotic deformities, with occupation of the vertebral canal. Among patients with a correct morphological study, 16% showed complete spinal cord transection and 12% showed only some tracts of tissue between the edges of the sectioned spinal cord. In 83% of cases intramedullary cysts were observed, with a mean volume of 0.95 ± 0.89 cc. Extensive cavitation, identified as post-traumatic syringomyelia was seen only in three patients. Varying degree of spinal cord atrophy, being generally segmental, was observed in over 60% of the patients. Conclusion: If according to preclinical studies, anatomical continuity of the spinal cord and limited intramedullary lesions are criteria for possible efficacy of cell therapy, these data suggest that only about 30% of patients with traumatic paraplegia chronically established, at dorsal level, could be reasonably valid for entry in first clinical trials." @default.
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- W2467228907 date "2014-01-01" @default.
- W2467228907 modified "2023-10-08" @default.
- W2467228907 title "Paraplejia traumática a nivel dorsal: alteraciones morfológicas de la médula espinal a largo plazo Traumatic paraplegia at thoracic level: Long-term morphological alterations in spinal cord" @default.
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