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- W2467315713 abstract "Abstract Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare aggressive tumor described in the midline in the chest and head and neck. Initially reported in younger individuals, it has subsequently been shown to have a wider age distribution. The defining feature of these tumors is its association with BRD-NUT rearrangements. Occasionally NMC has been observed in a non-midline location. This case report describes an unusual rapidly progressing non-midline hilar/endobronchial location of an NMC in a 34-year-old man. The clinical and histologic features were that of an undifferentiated neoplasm concerning for a small cell carcinoma or a lymphoma. A broad panel of immunohistochemical markers for carcinoma, lymphoma and melanoma were negative which led us to suspect a diagnosis of NMC. A positive immunostaining with p63 and NUT protein antigen confirmed the diagnosis. The p63 positivity and cytokeratin negativity suggest a primitive/precursor squamous cell derivation." @default.
- W2467315713 created "2016-07-22" @default.
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- W2467315713 date "2017-03-01" @default.
- W2467315713 modified "2023-09-23" @default.
- W2467315713 title "Hilar/endobronchial NUT midline carcinoma: A case report" @default.
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- W2467315713 doi "https://doi.org/10.1016/j.ehpc.2015.06.004" @default.
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