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- W2467501376 abstract "The effect of ethanolic turmeric extract (ETE) on murine lymphocytes vis-a-vis tumor cells was studied. in terms of its ability to activate lyinphocytcs and to induce apoptosis in tumor cells. Degree of activation and proliferation of lymphocytes treated with ETE was analyzed in terms of blastogenesis, DNA synthesis through 3 H-thymidine incorporation and cell cycle analysis by flourescence activated cell sorter (FACS). FACS analysis was also carried out to observe the proliferation as well as apoptosis of tumor cells. Morphological condition of both the cell types in presence of ETE was examined by scanning electron microscopy (SEM). Cytotoxic capability of ETE-treated effector T lymphocytes towards tumor cells was judged in vitro by Cr-release assay and tlie growth of tumor in situ. ETE stimulated murine lymphocytes towards blastogenesis and synthesis of DNA, as revealed by increased incorporation of 3 H-thymidine. FACS indicated that the lymphocytes were driven towards mitotic cycle by activating G 2 -M transition. In the same count, the tumor cells mostly remained accumulated in the G 2 -M phase. and thus mitotically arrested. Scanning electron photomicrographs revealed the blastoid transformation of lymphocytes and ETE-induced apoptotic condition of tumor cells. Furthermore, ETE-treated T cells were cytotoxic towards tumor cells in vitro, as shown by 51 Cr- release assay. ETE administered intravenously or orally could delay the onset and growth of tumor, and thus prolonged the life span of the tumor-bearing host. The present investigation suggests potential of turmeric both to destroy the malignant cells directly and via activation of the host's cellular immunity." @default.
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- W2467501376 date "2008-02-01" @default.
- W2467501376 modified "2023-09-26" @default.
- W2467501376 title "Activation of cell mediated immune response and apoptosis towards malignant cells with turmeric treatment in murine model" @default.
- W2467501376 hasPublicationYear "2008" @default.
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