Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467553206> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2467553206 endingPage "5" @default.
- W2467553206 startingPage "510" @default.
- W2467553206 abstract "To study the effect of magnesium sulfate on transient outward K+ current (IA) and delayed rectifier K+ current (IK) in freshly dissociated hippocampal neurons of rats.The whole-cell patch clamp techniques were used.Magnesium sulfate reversibly reduced the amplitudes of IA and IK in a concentration-dependent and voltage-dependent, but not frequency-dependent manner. Half-blocking concentration (IC50) on IA and IK were 6.30 mmol.L-1 and 7.60 mmol.L-1, respectively. Magnesium sulfate (6 mmol.L-1) affected the activation process of IA and IK. Before and after application of the drug, the half-activation voltages of IA were (7 +/- 6) mV and (-7 +/- 11) mV (n = 10, P < 0.01), and the half-activation voltages of IK were (20 +/- 6) mV and (28 +/- 4) mV (n = 10, P < 0.01), but the slope factors were not changed. In addition, magnesium sulfate (6 mmol.L-1) also affected the inactivation process of IA. Before and after application of the drug, the half-inactivation voltages of IA were (-65 +/- 5) mV and (-89 +/- 6) mV (n = 10, P < 0.01).Magnesium sulfate inhibited IA and IK in freshly dissociated hippocampal neurons of rats, which might contribute to protect the central neuronal system (CNS) against damages induced by ischemia and oxygen deprivation." @default.
- W2467553206 created "2016-07-22" @default.
- W2467553206 creator A5010389697 @default.
- W2467553206 creator A5038456429 @default.
- W2467553206 date "2002-07-01" @default.
- W2467553206 modified "2023-09-23" @default.
- W2467553206 title "[Blockade of magnesium sulfate on transient outward K+ current and delayed rectifier K+ current in acutely isolated rat hippocampal neurons]." @default.
- W2467553206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12914319" @default.
- W2467553206 hasPublicationYear "2002" @default.
- W2467553206 type Work @default.
- W2467553206 sameAs 2467553206 @default.
- W2467553206 citedByCount "0" @default.
- W2467553206 crossrefType "journal-article" @default.
- W2467553206 hasAuthorship W2467553206A5010389697 @default.
- W2467553206 hasAuthorship W2467553206A5038456429 @default.
- W2467553206 hasConcept C100837961 @default.
- W2467553206 hasConcept C12554922 @default.
- W2467553206 hasConcept C126322002 @default.
- W2467553206 hasConcept C134018914 @default.
- W2467553206 hasConcept C147944092 @default.
- W2467553206 hasConcept C148762608 @default.
- W2467553206 hasConcept C170493617 @default.
- W2467553206 hasConcept C178790620 @default.
- W2467553206 hasConcept C181911157 @default.
- W2467553206 hasConcept C185263204 @default.
- W2467553206 hasConcept C185592680 @default.
- W2467553206 hasConcept C543218039 @default.
- W2467553206 hasConcept C55493867 @default.
- W2467553206 hasConcept C71924100 @default.
- W2467553206 hasConcept C86803240 @default.
- W2467553206 hasConceptScore W2467553206C100837961 @default.
- W2467553206 hasConceptScore W2467553206C12554922 @default.
- W2467553206 hasConceptScore W2467553206C126322002 @default.
- W2467553206 hasConceptScore W2467553206C134018914 @default.
- W2467553206 hasConceptScore W2467553206C147944092 @default.
- W2467553206 hasConceptScore W2467553206C148762608 @default.
- W2467553206 hasConceptScore W2467553206C170493617 @default.
- W2467553206 hasConceptScore W2467553206C178790620 @default.
- W2467553206 hasConceptScore W2467553206C181911157 @default.
- W2467553206 hasConceptScore W2467553206C185263204 @default.
- W2467553206 hasConceptScore W2467553206C185592680 @default.
- W2467553206 hasConceptScore W2467553206C543218039 @default.
- W2467553206 hasConceptScore W2467553206C55493867 @default.
- W2467553206 hasConceptScore W2467553206C71924100 @default.
- W2467553206 hasConceptScore W2467553206C86803240 @default.
- W2467553206 hasIssue "7" @default.
- W2467553206 hasLocation W24675532061 @default.
- W2467553206 hasOpenAccess W2467553206 @default.
- W2467553206 hasPrimaryLocation W24675532061 @default.
- W2467553206 hasRelatedWork W2032677026 @default.
- W2467553206 hasRelatedWork W2057141486 @default.
- W2467553206 hasRelatedWork W2058218238 @default.
- W2467553206 hasRelatedWork W2080971681 @default.
- W2467553206 hasRelatedWork W2087734597 @default.
- W2467553206 hasRelatedWork W2153847623 @default.
- W2467553206 hasRelatedWork W2361574377 @default.
- W2467553206 hasRelatedWork W2381102460 @default.
- W2467553206 hasRelatedWork W2412501758 @default.
- W2467553206 hasRelatedWork W2463316005 @default.
- W2467553206 hasVolume "37" @default.
- W2467553206 isParatext "false" @default.
- W2467553206 isRetracted "false" @default.
- W2467553206 magId "2467553206" @default.
- W2467553206 workType "article" @default.