FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467616276> ?p ?o ?g. }

• W2467616276 endingPage "2700" @default.
• W2467616276 startingPage "2692" @default.
• W2467616276 abstract "Context: Although response to therapy assessment is a validated tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC) treated with total thyroidectomy (TT) and radioactive iodine therapy (RAI), it has not been well studied in patients treated with lobectomy or TT without RAI. Because these responses to therapy definitions are heavily dependent on serum thyroglobulin (Tg) levels, modifications of the original definitions were needed to appropriately classify patients treated without RAI. Objective: This study aimed to validate the response to therapy assessment in patients with DTC treated with lobectomy or TT without RAI. Design and Setting: This was a retrospective study, which took place at a referral center. Patients: A total of 507 adults with DTC were treated with lobectomy (n = 187) or TT (n = 320) without RAI. They had a median age of 43.7 y, 88% were female, 85.4% had low risk, and 14.6% intermediate risk. Main Outcome Measure: Main outcome measured was recurrent/persistent structural evidence of disease (SED) during a median followup period of 100.5 months (24–510). Results: Recurrent/persistent SED was observed in 0% of the patients with excellent response to therapy (nonstimulated Tg for TT &lt; 0.2 ng/mL and for lobectomy &lt; 30 ng/mL, undetectable Tg antibodies [TgAb] and negative imaging; n = 326); 1.3% with indeterminate response (nonstimulated Tg for TT 0.2–5 ng/mL, stable or declining TgAb and/or nonspecific imaging findings; n = 2/152); 31.6% of the patients with biochemical incomplete response (nonstimulated Tg for TT &gt; 5 ng/mL and for lobectomy &gt; 30 ng/mL and/or increasing Tg with similar TSH levels and/or increasing TgAb and negative imaging; n = 6/19) and all (100%) patients with structural incomplete response (n = 10/10) (P &lt; .0001). Initial American Thyroid Association risk estimates were significantly modified based on response to therapy assessment. Conclusions: Our data validate the newly proposed response to therapy assessment in patients with DTC treated with lobectomy or TT without RAI as an effective tool to modify initial risk estimates of recurrent/persistent SED and better tailor followup and future therapeutic approaches. This study provides further evidence to support a selective use of RAI in DTC." @default.
• W2467616276 created "2016-07-22" @default.
• W2467616276 creator A5009898984 @default.
• W2467616276 creator A5044682184 @default.
• W2467616276 creator A5048882065 @default.
• W2467616276 creator A5064244607 @default.
• W2467616276 creator A5065895333 @default.
• W2467616276 creator A5077311174 @default.
• W2467616276 creator A5088636765 @default.
• W2467616276 date "2016-07-01" @default.
• W2467616276 modified "2023-10-05" @default.
• W2467616276 title "Dynamic Risk Stratification in Patients with Differentiated Thyroid Cancer Treated Without Radioactive Iodine" @default.
• W2467616276 cites W1483372455 @default.
• W2467616276 cites W1623870544 @default.
• W2467616276 cites W1971307668 @default.
• W2467616276 cites W1979783540 @default.
• W2467616276 cites W1984135618 @default.
• W2467616276 cites W1987472852 @default.
• W2467616276 cites W1999920710 @default.
• W2467616276 cites W2006964912 @default.
• W2467616276 cites W2019664090 @default.
• W2467616276 cites W2034542445 @default.
• W2467616276 cites W2041923011 @default.
• W2467616276 cites W2043226535 @default.
• W2467616276 cites W2046781127 @default.
• W2467616276 cites W2053272999 @default.
• W2467616276 cites W2055333583 @default.
• W2467616276 cites W2057242573 @default.
• W2467616276 cites W2070063492 @default.
• W2467616276 cites W2085347450 @default.
• W2467616276 cites W2101525911 @default.
• W2467616276 cites W2101988780 @default.
• W2467616276 cites W2110829017 @default.
• W2467616276 cites W2125403642 @default.
• W2467616276 cites W2132296761 @default.
• W2467616276 cites W2132334720 @default.
• W2467616276 cites W2145150141 @default.
• W2467616276 cites W2163175491 @default.
• W2467616276 cites W4231667321 @default.
• W2467616276 cites W4362127578 @default.
• W2467616276 doi "https://doi.org/10.1210/jc.2015-4290" @default.
• W2467616276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6287503" @default.
• W2467616276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27023446" @default.
• W2467616276 hasPublicationYear "2016" @default.
• W2467616276 type Work @default.
• W2467616276 sameAs 2467616276 @default.
• W2467616276 citedByCount "165" @default.
• W2467616276 countsByYear W24676162762016 @default.
• W2467616276 countsByYear W24676162762017 @default.
• W2467616276 countsByYear W24676162762018 @default.
• W2467616276 countsByYear W24676162762019 @default.
• W2467616276 countsByYear W24676162762020 @default.
• W2467616276 countsByYear W24676162762021 @default.
• W2467616276 countsByYear W24676162762022 @default.
• W2467616276 countsByYear W24676162762023 @default.
• W2467616276 crossrefType "journal-article" @default.
• W2467616276 hasAuthorship W2467616276A5009898984 @default.
• W2467616276 hasAuthorship W2467616276A5044682184 @default.
• W2467616276 hasAuthorship W2467616276A5048882065 @default.
• W2467616276 hasAuthorship W2467616276A5064244607 @default.
• W2467616276 hasAuthorship W2467616276A5065895333 @default.
• W2467616276 hasAuthorship W2467616276A5077311174 @default.
• W2467616276 hasAuthorship W2467616276A5088636765 @default.
• W2467616276 hasBestOaLocation W24676162761 @default.
• W2467616276 hasConcept C126322002 @default.
• W2467616276 hasConcept C134018914 @default.
• W2467616276 hasConcept C151730666 @default.
• W2467616276 hasConcept C167135981 @default.
• W2467616276 hasConcept C2777074255 @default.
• W2467616276 hasConcept C2778835679 @default.
• W2467616276 hasConcept C2779343474 @default.
• W2467616276 hasConcept C2779761222 @default.
• W2467616276 hasConcept C2989005 @default.
• W2467616276 hasConcept C526584372 @default.
• W2467616276 hasConcept C71924100 @default.
• W2467616276 hasConcept C86803240 @default.
• W2467616276 hasConcept C90924648 @default.
• W2467616276 hasConceptScore W2467616276C126322002 @default.
• W2467616276 hasConceptScore W2467616276C134018914 @default.
• W2467616276 hasConceptScore W2467616276C151730666 @default.
• W2467616276 hasConceptScore W2467616276C167135981 @default.
• W2467616276 hasConceptScore W2467616276C2777074255 @default.
• W2467616276 hasConceptScore W2467616276C2778835679 @default.
• W2467616276 hasConceptScore W2467616276C2779343474 @default.
• W2467616276 hasConceptScore W2467616276C2779761222 @default.
• W2467616276 hasConceptScore W2467616276C2989005 @default.
• W2467616276 hasConceptScore W2467616276C526584372 @default.
• W2467616276 hasConceptScore W2467616276C71924100 @default.
• W2467616276 hasConceptScore W2467616276C86803240 @default.
• W2467616276 hasConceptScore W2467616276C90924648 @default.
• W2467616276 hasIssue "7" @default.
• W2467616276 hasLocation W24676162761 @default.
• W2467616276 hasLocation W24676162762 @default.
• W2467616276 hasLocation W24676162763 @default.
• W2467616276 hasLocation W24676162764 @default.
• W2467616276 hasOpenAccess W2467616276 @default.
• W2467616276 hasPrimaryLocation W24676162761 @default.
• W2467616276 hasRelatedWork W1972113515 @default.

• next