Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467670187> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2467670187 abstract "Our incomplete understanding of the critical changes that accompany the earliest stages of tumor initiation provides a substantial hurdle for the development of novel intervention strategies for cancer prevention. Premalignant lesions are inherently difficult to characterize given their diminutive size, creating technical obstacles for accurate genetic profiling. Here, we describe an approach combining laser-capture microdissection (LCM) with targeted RNA-sequencing to study the transcriptional state of epithelial and stromal cells during the earliest detectable stage of human colorectal neoplasia, the aberrant crypt foci (ACF). We provide a robust and reproducible workflow for RNA isolation, library preparation, and expression profiling of laser-captured cells from frozen OCT-embedded tissue specimens. It is anticipated that the methodological approach outlined in this report will provide a framework for a broad range of microgenomics analyses that can be routinely applied to many other premalignant tissues. J. Cell. Biochem. 117: 2677-2681, 2016. © 2016 Wiley Periodicals, Inc." @default.
- W2467670187 created "2016-07-22" @default.
- W2467670187 creator A5035461961 @default.
- W2467670187 creator A5039719627 @default.
- W2467670187 creator A5066895730 @default.
- W2467670187 creator A5068167623 @default.
- W2467670187 date "2016-07-12" @default.
- W2467670187 modified "2023-10-17" @default.
- W2467670187 title "Targeted Transcriptional Profiling of Microdissected Biopsy Specimens Representing Early Colonic Neoplasia" @default.
- W2467670187 cites W1762951073 @default.
- W2467670187 cites W1984984201 @default.
- W2467670187 cites W1985343297 @default.
- W2467670187 cites W1986163307 @default.
- W2467670187 cites W2009847758 @default.
- W2467670187 cites W2088284538 @default.
- W2467670187 cites W2096192437 @default.
- W2467670187 cites W2099851046 @default.
- W2467670187 cites W2103543394 @default.
- W2467670187 cites W2107229687 @default.
- W2467670187 cites W2109847775 @default.
- W2467670187 cites W2113813261 @default.
- W2467670187 cites W2128610155 @default.
- W2467670187 cites W2157490878 @default.
- W2467670187 cites W2168273902 @default.
- W2467670187 cites W2178888844 @default.
- W2467670187 cites W2257647775 @default.
- W2467670187 cites W2343956310 @default.
- W2467670187 cites W2461313752 @default.
- W2467670187 doi "https://doi.org/10.1002/jcb.25644" @default.
- W2467670187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27357168" @default.
- W2467670187 hasPublicationYear "2016" @default.
- W2467670187 type Work @default.
- W2467670187 sameAs 2467670187 @default.
- W2467670187 citedByCount "3" @default.
- W2467670187 countsByYear W24676701872017 @default.
- W2467670187 countsByYear W24676701872018 @default.
- W2467670187 countsByYear W24676701872020 @default.
- W2467670187 crossrefType "journal-article" @default.
- W2467670187 hasAuthorship W2467670187A5035461961 @default.
- W2467670187 hasAuthorship W2467670187A5039719627 @default.
- W2467670187 hasAuthorship W2467670187A5066895730 @default.
- W2467670187 hasAuthorship W2467670187A5068167623 @default.
- W2467670187 hasConcept C104317684 @default.
- W2467670187 hasConcept C11242284 @default.
- W2467670187 hasConcept C125965507 @default.
- W2467670187 hasConcept C142724271 @default.
- W2467670187 hasConcept C150194340 @default.
- W2467670187 hasConcept C16930146 @default.
- W2467670187 hasConcept C2775934546 @default.
- W2467670187 hasConcept C502942594 @default.
- W2467670187 hasConcept C54355233 @default.
- W2467670187 hasConcept C67705224 @default.
- W2467670187 hasConcept C70721500 @default.
- W2467670187 hasConcept C71924100 @default.
- W2467670187 hasConcept C86803240 @default.
- W2467670187 hasConceptScore W2467670187C104317684 @default.
- W2467670187 hasConceptScore W2467670187C11242284 @default.
- W2467670187 hasConceptScore W2467670187C125965507 @default.
- W2467670187 hasConceptScore W2467670187C142724271 @default.
- W2467670187 hasConceptScore W2467670187C150194340 @default.
- W2467670187 hasConceptScore W2467670187C16930146 @default.
- W2467670187 hasConceptScore W2467670187C2775934546 @default.
- W2467670187 hasConceptScore W2467670187C502942594 @default.
- W2467670187 hasConceptScore W2467670187C54355233 @default.
- W2467670187 hasConceptScore W2467670187C67705224 @default.
- W2467670187 hasConceptScore W2467670187C70721500 @default.
- W2467670187 hasConceptScore W2467670187C71924100 @default.
- W2467670187 hasConceptScore W2467670187C86803240 @default.
- W2467670187 hasFunder F4320308040 @default.
- W2467670187 hasFunder F4320337351 @default.
- W2467670187 hasLocation W24676701871 @default.
- W2467670187 hasLocation W24676701872 @default.
- W2467670187 hasOpenAccess W2467670187 @default.
- W2467670187 hasPrimaryLocation W24676701871 @default.
- W2467670187 hasRelatedWork W1905272232 @default.
- W2467670187 hasRelatedWork W1972380726 @default.
- W2467670187 hasRelatedWork W2067565909 @default.
- W2467670187 hasRelatedWork W2142289089 @default.
- W2467670187 hasRelatedWork W2165153892 @default.
- W2467670187 hasRelatedWork W2412825278 @default.
- W2467670187 hasRelatedWork W2910033560 @default.
- W2467670187 hasRelatedWork W2981986061 @default.
- W2467670187 hasRelatedWork W4285096964 @default.
- W2467670187 hasRelatedWork W90202899 @default.
- W2467670187 isParatext "false" @default.
- W2467670187 isRetracted "false" @default.
- W2467670187 magId "2467670187" @default.
- W2467670187 workType "article" @default.