Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467756948> ?p ?o ?g. }
- W2467756948 endingPage "30" @default.
- W2467756948 startingPage "13" @default.
- W2467756948 abstract "Guanine nucleotide-binding proteins of the inhibitory (Gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5HT1a, etc.). Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins. The redundant actions of the 20 different RGS family members have made it difficult to establish their overall physiological role. A unique G protein mutation (G184S in Gαi/o) prevents RGS binding to the Gα subunit and blocks all RGS action at that particular Gα subunit. The robust phenotypes of mice expressing these RGS-insensitive (RGSi) mutant G proteins illustrate the profound action of RGS proteins in cardiovascular, metabolic, and central nervous system functions. Specifically, the enhanced Gαi2 signaling through the RGSi Gαi2(G184S) mutant knock-in mice shows protection against cardiac ischemia/reperfusion injury and potentiation of serotonin-mediated antidepressant actions. In contrast, the RGSi Gαo mutant knock-in produces enhanced mu-opioid receptor-mediated analgesia but also a seizure phenotype. These genetic models provide novel insights into potential therapeutic strategies related to RGS protein inhibitors and/or G protein subtype-biased agonists at particular GPCRs." @default.
- W2467756948 created "2016-07-22" @default.
- W2467756948 creator A5016819654 @default.
- W2467756948 date "2015-01-01" @default.
- W2467756948 modified "2023-10-18" @default.
- W2467756948 title "RGS-Insensitive G Proteins as In Vivo Probes of RGS Function" @default.
- W2467756948 cites W1508249425 @default.
- W2467756948 cites W1515479627 @default.
- W2467756948 cites W1517938530 @default.
- W2467756948 cites W1538879480 @default.
- W2467756948 cites W1583750739 @default.
- W2467756948 cites W1935225932 @default.
- W2467756948 cites W1972929216 @default.
- W2467756948 cites W1974229569 @default.
- W2467756948 cites W1986781302 @default.
- W2467756948 cites W1989817592 @default.
- W2467756948 cites W1992229507 @default.
- W2467756948 cites W1993746910 @default.
- W2467756948 cites W1996542598 @default.
- W2467756948 cites W2000947301 @default.
- W2467756948 cites W2004202674 @default.
- W2467756948 cites W2005614924 @default.
- W2467756948 cites W2015447367 @default.
- W2467756948 cites W2016787304 @default.
- W2467756948 cites W2017070450 @default.
- W2467756948 cites W2018483093 @default.
- W2467756948 cites W2019560470 @default.
- W2467756948 cites W2023396177 @default.
- W2467756948 cites W2025172491 @default.
- W2467756948 cites W2029445497 @default.
- W2467756948 cites W2031509730 @default.
- W2467756948 cites W2031818710 @default.
- W2467756948 cites W2033717464 @default.
- W2467756948 cites W2039981221 @default.
- W2467756948 cites W2041407510 @default.
- W2467756948 cites W2042421949 @default.
- W2467756948 cites W2048351462 @default.
- W2467756948 cites W2050905518 @default.
- W2467756948 cites W2053217010 @default.
- W2467756948 cites W2054695075 @default.
- W2467756948 cites W2056656988 @default.
- W2467756948 cites W2066015662 @default.
- W2467756948 cites W2067441205 @default.
- W2467756948 cites W2080308963 @default.
- W2467756948 cites W2087714175 @default.
- W2467756948 cites W2088700210 @default.
- W2467756948 cites W2092486392 @default.
- W2467756948 cites W2094672699 @default.
- W2467756948 cites W2098020565 @default.
- W2467756948 cites W2102140340 @default.
- W2467756948 cites W2104628564 @default.
- W2467756948 cites W2108280966 @default.
- W2467756948 cites W2108617639 @default.
- W2467756948 cites W2110458673 @default.
- W2467756948 cites W2111542614 @default.
- W2467756948 cites W2111965328 @default.
- W2467756948 cites W2120976060 @default.
- W2467756948 cites W2123491442 @default.
- W2467756948 cites W2125216942 @default.
- W2467756948 cites W2131374289 @default.
- W2467756948 cites W2146210241 @default.
- W2467756948 cites W2146319155 @default.
- W2467756948 cites W2148074284 @default.
- W2467756948 cites W2149353937 @default.
- W2467756948 cites W2150100254 @default.
- W2467756948 cites W2150802452 @default.
- W2467756948 cites W2156802607 @default.
- W2467756948 cites W2160612626 @default.
- W2467756948 cites W2162393779 @default.
- W2467756948 cites W2162842869 @default.
- W2467756948 cites W2167441016 @default.
- W2467756948 cites W2273410316 @default.
- W2467756948 cites W2418067034 @default.
- W2467756948 cites W4254470334 @default.
- W2467756948 doi "https://doi.org/10.1016/bs.pmbts.2015.04.010" @default.
- W2467756948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26123300" @default.
- W2467756948 hasPublicationYear "2015" @default.
- W2467756948 type Work @default.
- W2467756948 sameAs 2467756948 @default.
- W2467756948 citedByCount "18" @default.
- W2467756948 countsByYear W24677569482015 @default.
- W2467756948 countsByYear W24677569482016 @default.
- W2467756948 countsByYear W24677569482017 @default.
- W2467756948 countsByYear W24677569482018 @default.
- W2467756948 countsByYear W24677569482020 @default.
- W2467756948 countsByYear W24677569482021 @default.
- W2467756948 countsByYear W24677569482023 @default.
- W2467756948 crossrefType "book-chapter" @default.
- W2467756948 hasAuthorship W2467756948A5016819654 @default.
- W2467756948 hasConcept C104292427 @default.
- W2467756948 hasConcept C104317684 @default.
- W2467756948 hasConcept C135285700 @default.
- W2467756948 hasConcept C143065580 @default.
- W2467756948 hasConcept C163181125 @default.
- W2467756948 hasConcept C185592680 @default.
- W2467756948 hasConcept C2777993845 @default.
- W2467756948 hasConcept C4963665 @default.
- W2467756948 hasConcept C55493867 @default.