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- W2467764477 abstract "In anesthetized pigs, the influence on cardiovascular performance and on survival rate of IV administration of a large dose of endotoxin (0.5 mg/kg of body weight) was examined. This dose of endotoxin (LD100) resulted in a progressively evolving deterioration of cardiovascular functions and in the death of all animals within 210 minutes (mean +/- SEM: 107 +/- 13 minutes) after it was given. The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time. This effect of the glycocorticoid can only partly be ascribed to an amelioration of the cardiovascular dysfunctions." @default.
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- W2467764477 date "1984-08-01" @default.
- W2467764477 modified "2023-09-23" @default.
- W2467764477 title "Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate." @default.
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