FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467881331> ?p ?o ?g. }

• W2467881331 endingPage "507" @default.
• W2467881331 startingPage "496" @default.
• W2467881331 abstract "Developmental constraints force the early egg to adopt an unusual biology. Normal biological controls are introduced in a rapid but progressive sequence, which we exemplify by changes in key cell cycle regulators that slow and regularize the cell cycle. This succession of regulatory changes contrasts to the usual depiction of the rapid transformation prior to gastrulation as a monolithic switch called the MBT. While there are some particularly decisive steps, the entire progression is temporally stereotyped. Thus the MBT, while rapid and transformative, should be considered as a developmental process that engages much of the biology of embryo. Progressive changes in Cdk1, an influential cell cycle kinase, coordinate much of this developmental program. At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes. At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes." @default.
• W2467881331 created "2016-07-22" @default.
• W2467881331 creator A5021751458 @default.
• W2467881331 creator A5040032270 @default.
• W2467881331 creator A5054474872 @default.
• W2467881331 creator A5086364138 @default.
• W2467881331 date "2016-08-01" @default.
• W2467881331 modified "2023-09-30" @default.
• W2467881331 title "Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View" @default.
• W2467881331 cites W1507334568 @default.
• W2467881331 cites W1576910771 @default.
• W2467881331 cites W1966435085 @default.
• W2467881331 cites W1973447179 @default.
• W2467881331 cites W1979315404 @default.
• W2467881331 cites W1983089322 @default.
• W2467881331 cites W1984046181 @default.
• W2467881331 cites W1984688123 @default.
• W2467881331 cites W1988745695 @default.
• W2467881331 cites W1992767260 @default.
• W2467881331 cites W1993777905 @default.
• W2467881331 cites W1995210728 @default.
• W2467881331 cites W1997721662 @default.
• W2467881331 cites W2000789135 @default.
• W2467881331 cites W2001536227 @default.
• W2467881331 cites W2004798712 @default.
• W2467881331 cites W2006220656 @default.
• W2467881331 cites W2007283637 @default.
• W2467881331 cites W2009277631 @default.
• W2467881331 cites W2010435445 @default.
• W2467881331 cites W2011031824 @default.
• W2467881331 cites W2012999862 @default.
• W2467881331 cites W2014186431 @default.
• W2467881331 cites W2014957927 @default.
• W2467881331 cites W2014993354 @default.
• W2467881331 cites W2029148787 @default.
• W2467881331 cites W2035298842 @default.
• W2467881331 cites W2040461990 @default.
• W2467881331 cites W2048704419 @default.
• W2467881331 cites W2057591834 @default.
• W2467881331 cites W2064154094 @default.
• W2467881331 cites W2072267393 @default.
• W2467881331 cites W2073652940 @default.
• W2467881331 cites W2077592586 @default.
• W2467881331 cites W2081180790 @default.
• W2467881331 cites W2081732195 @default.
• W2467881331 cites W2083942739 @default.
• W2467881331 cites W2083971905 @default.
• W2467881331 cites W2084271768 @default.
• W2467881331 cites W2088529761 @default.
• W2467881331 cites W2098934384 @default.
• W2467881331 cites W2103431676 @default.
• W2467881331 cites W2105284425 @default.
• W2467881331 cites W2105602166 @default.
• W2467881331 cites W2105656306 @default.
• W2467881331 cites W2107332774 @default.
• W2467881331 cites W2107757466 @default.
• W2467881331 cites W2107974267 @default.
• W2467881331 cites W2115613196 @default.
• W2467881331 cites W2119731001 @default.
• W2467881331 cites W2126607589 @default.
• W2467881331 cites W2126704867 @default.
• W2467881331 cites W2130963936 @default.
• W2467881331 cites W2131228147 @default.
• W2467881331 cites W2133220272 @default.
• W2467881331 cites W2135112382 @default.
• W2467881331 cites W2136644864 @default.
• W2467881331 cites W2138163955 @default.
• W2467881331 cites W2140042191 @default.
• W2467881331 cites W2144942522 @default.
• W2467881331 cites W2146414105 @default.
• W2467881331 cites W2147925889 @default.
• W2467881331 cites W2148019518 @default.
• W2467881331 cites W2148163836 @default.
• W2467881331 cites W2150152014 @default.
• W2467881331 cites W2151836800 @default.
• W2467881331 cites W2152115601 @default.
• W2467881331 cites W2152927233 @default.
• W2467881331 cites W2154065009 @default.
• W2467881331 cites W2154551082 @default.
• W2467881331 cites W2155896486 @default.
• W2467881331 cites W2164483458 @default.
• W2467881331 cites W2166840544 @default.
• W2467881331 cites W2167986457 @default.
• W2467881331 cites W2170073563 @default.
• W2467881331 cites W2185571529 @default.
• W2467881331 cites W2285137632 @default.
• W2467881331 cites W2331639432 @default.
• W2467881331 cites W2416629879 @default.
• W2467881331 cites W2469496497 @default.
• W2467881331 cites W2473815127 @default.
• W2467881331 cites W4254349835 @default.
• W2467881331 doi "https://doi.org/10.1016/j.tig.2016.05.006" @default.
• W2467881331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4958567" @default.
• W2467881331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27339317" @default.
• W2467881331 hasPublicationYear "2016" @default.
• W2467881331 type Work @default.
• W2467881331 sameAs 2467881331 @default.
• W2467881331 citedByCount "71" @default.

• next