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- W2467933133 abstract "Systemic Lupus Erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. Metabolic and functional alterations result in peripheral tolerance failures and biased differentiation of T cells into pro-inflammatory and B cell-helper phenotypes as well as the accumulation of disease-promoting memory T cells. Understanding these T cell alterations and their origins is necessary to develop more accurate patient classification systems and to discover new therapeutic targets." @default.
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- W2467933133 date "2016-12-01" @default.
- W2467933133 modified "2023-10-02" @default.
- W2467933133 title "T cells in Systemic Lupus Erythematosus" @default.
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- W2467933133 doi "https://doi.org/10.1016/j.coi.2016.09.001" @default.
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