FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467939795> ?p ?o ?g. }

• W2467939795 abstract "Trichinellosis, a widespread zoonosis, is considered to be an emerging or re-emerging infectious parasitic disease. The development of vaccines to prevent Trichinella infection in domestic animals and humans is important for disease control. In a previous study, we identified Ts14-3-3 as an immunodominant protein from Trichinella spiralis (T. spiralis) adult worms recognized by early infection sera from pigs and mice. In this study, we further confirmed that Ts14-3-3 mRNA is expressed in both adult worms and in the larval stages of T. spiralis. Immunostaining with anti-Ts14-3-3 mouse sera further confirmed that native Ts14-3-3 is highly expressed on the surface of T. spiralis muscle larvae. The immune recognition by infected sera, its expression in both adult and larval stages and its exposure on the surface of the parasite led us to explore Ts14-3-3 as a vaccine antigen. Recombinant Ts14-3-3 formulated with an ISA50v2 adjuvant produced strong total IgG and balanced IgG1 and IgG2a responses in vaccinated mice and stimulated mouse splenocytes to produce high levels of Th1 (INF-γ, IL-2) and Th2 (IL4, IL5) cytokines. These results indicate that Ts14-3-3 is highly immunogenic and is able to induce balanced Th1/Th2 immune responses. These vaccine-induced immune responses resulted in a reduction in muscle larvae of up to 46.2% in vaccinated mice upon subsequent larval challenge relative to the number of larvae in mice received PBS control. The significant reduction in muscle larvae in vaccinated mice suggests that Ts14-3-3 is a promising vaccine target for potential use in domestic pigs to prevent trichinellosis transmission." @default.
• W2467939795 created "2016-07-22" @default.
• W2467939795 creator A5006744434 @default.
• W2467939795 creator A5015916611 @default.
• W2467939795 creator A5020411177 @default.
• W2467939795 creator A5021031074 @default.
• W2467939795 creator A5042786497 @default.
• W2467939795 creator A5048792156 @default.
• W2467939795 creator A5084985894 @default.
• W2467939795 date "2016-11-01" @default.
• W2467939795 modified "2023-10-15" @default.
• W2467939795 title "Partially protective immunity induced by the 14-3-3 protein from Trichinella spiralis" @default.
• W2467939795 cites W1516385366 @default.
• W2467939795 cites W1906523295 @default.
• W2467939795 cites W1952765928 @default.
• W2467939795 cites W1965301094 @default.
• W2467939795 cites W1966253417 @default.
• W2467939795 cites W1979629723 @default.
• W2467939795 cites W1985043193 @default.
• W2467939795 cites W1991876677 @default.
• W2467939795 cites W1997218289 @default.
• W2467939795 cites W1999346337 @default.
• W2467939795 cites W2020701970 @default.
• W2467939795 cites W2020715442 @default.
• W2467939795 cites W2033782276 @default.
• W2467939795 cites W2039635466 @default.
• W2467939795 cites W2044119466 @default.
• W2467939795 cites W2050566629 @default.
• W2467939795 cites W2054193391 @default.
• W2467939795 cites W2057805290 @default.
• W2467939795 cites W2058410965 @default.
• W2467939795 cites W2079484247 @default.
• W2467939795 cites W2083272369 @default.
• W2467939795 cites W2089806453 @default.
• W2467939795 cites W2103463718 @default.
• W2467939795 cites W2111593150 @default.
• W2467939795 cites W2121451463 @default.
• W2467939795 cites W2126823935 @default.
• W2467939795 cites W2127014133 @default.
• W2467939795 cites W2128562468 @default.
• W2467939795 cites W2151295105 @default.
• W2467939795 cites W2167014362 @default.
• W2467939795 cites W2259922782 @default.
• W2467939795 cites W2988513128 @default.
• W2467939795 cites W2077677011 @default.
• W2467939795 doi "https://doi.org/10.1016/j.vetpar.2016.06.028" @default.
• W2467939795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27387374" @default.
• W2467939795 hasPublicationYear "2016" @default.
• W2467939795 type Work @default.
• W2467939795 sameAs 2467939795 @default.
• W2467939795 citedByCount "24" @default.
• W2467939795 countsByYear W24679397952016 @default.
• W2467939795 countsByYear W24679397952017 @default.
• W2467939795 countsByYear W24679397952018 @default.
• W2467939795 countsByYear W24679397952020 @default.
• W2467939795 countsByYear W24679397952021 @default.
• W2467939795 countsByYear W24679397952022 @default.
• W2467939795 crossrefType "journal-article" @default.
• W2467939795 hasAuthorship W2467939795A5006744434 @default.
• W2467939795 hasAuthorship W2467939795A5015916611 @default.
• W2467939795 hasAuthorship W2467939795A5020411177 @default.
• W2467939795 hasAuthorship W2467939795A5021031074 @default.
• W2467939795 hasAuthorship W2467939795A5042786497 @default.
• W2467939795 hasAuthorship W2467939795A5048792156 @default.
• W2467939795 hasAuthorship W2467939795A5084985894 @default.
• W2467939795 hasConcept C147483822 @default.
• W2467939795 hasConcept C159047783 @default.
• W2467939795 hasConcept C165901193 @default.
• W2467939795 hasConcept C189976730 @default.
• W2467939795 hasConcept C203014093 @default.
• W2467939795 hasConcept C2777581317 @default.
• W2467939795 hasConcept C2777863537 @default.
• W2467939795 hasConcept C2779341262 @default.
• W2467939795 hasConcept C2780638806 @default.
• W2467939795 hasConcept C2780868878 @default.
• W2467939795 hasConcept C2781320125 @default.
• W2467939795 hasConcept C86803240 @default.
• W2467939795 hasConcept C8891405 @default.
• W2467939795 hasConcept C89423630 @default.
• W2467939795 hasConceptScore W2467939795C147483822 @default.
• W2467939795 hasConceptScore W2467939795C159047783 @default.
• W2467939795 hasConceptScore W2467939795C165901193 @default.
• W2467939795 hasConceptScore W2467939795C189976730 @default.
• W2467939795 hasConceptScore W2467939795C203014093 @default.
• W2467939795 hasConceptScore W2467939795C2777581317 @default.
• W2467939795 hasConceptScore W2467939795C2777863537 @default.
• W2467939795 hasConceptScore W2467939795C2779341262 @default.
• W2467939795 hasConceptScore W2467939795C2780638806 @default.
• W2467939795 hasConceptScore W2467939795C2780868878 @default.
• W2467939795 hasConceptScore W2467939795C2781320125 @default.
• W2467939795 hasConceptScore W2467939795C86803240 @default.
• W2467939795 hasConceptScore W2467939795C8891405 @default.
• W2467939795 hasConceptScore W2467939795C89423630 @default.
• W2467939795 hasFunder F4320321001 @default.
• W2467939795 hasLocation W24679397951 @default.
• W2467939795 hasLocation W24679397952 @default.
• W2467939795 hasOpenAccess W2467939795 @default.
• W2467939795 hasPrimaryLocation W24679397951 @default.
• W2467939795 hasRelatedWork W1978737089 @default.
• W2467939795 hasRelatedWork W2014607019 @default.

• next