FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467960635> ?p ?o ?g. }

• W2467960635 endingPage "1044" @default.
• W2467960635 startingPage "1038" @default.
• W2467960635 abstract "Transforming growth factor-β1 (TGF-β1), a potent inducer of epithelial-to-mesenchymal transition (EMT), upregulates the cold-inducible RNA-binding protein (CIRP). The link between CIRP and EMT, however, remains unknown. To determine the role of CIRP in EMT, we performed CIRP knockdown and overexpression experiments in in vitro TGF-β1-induced EMT models. We found that CIRP overexpression promoted the downregulation of epithelial markers and the upregulation of mesenchymal markers after TGF-β1 treatment for EMT induction. It also promoted cell migration and invasion, key features of EMT. In contrast, CIRP knockdown inhibited the downregulation of epithelial markers and the upregulation of mesenchymal markers after TGF-β1 treatment for EMT induction. In addition, it also inhibited cell migration and invasion. Furthermore, we demonstrated that the RNA-recognition motif in CIRP is essential for the role of CIRP in EMT. At the downstream level, CIRP knockdown downregulated Snail, key transcriptional regulator of EMT, while CIRP overexpression upregulated it. We found out that the link between CIRP and Snail is mediated by ERK and p38 pathways. EMT is a critical component of carcinoma metastasis and invasion. As demonstrated in this study, the biological role of CIRP in EMT may explain why CIRP overexpression has been associated with a bad prognosis in cancer patients." @default.
• W2467960635 created "2016-07-22" @default.
• W2467960635 creator A5013162352 @default.
• W2467960635 creator A5043801433 @default.
• W2467960635 creator A5050433869 @default.
• W2467960635 date "2016-09-01" @default.
• W2467960635 modified "2023-10-10" @default.
• W2467960635 title "Cold-inducible RNA-binding protein promotes epithelial-mesenchymal transition by activating ERK and p38 pathways" @default.
• W2467960635 cites W1951049964 @default.
• W2467960635 cites W1964847767 @default.
• W2467960635 cites W1965037168 @default.
• W2467960635 cites W1966557314 @default.
• W2467960635 cites W1992623236 @default.
• W2467960635 cites W1995128552 @default.
• W2467960635 cites W1995462963 @default.
• W2467960635 cites W1997535872 @default.
• W2467960635 cites W1999132074 @default.
• W2467960635 cites W2004142580 @default.
• W2467960635 cites W2009462679 @default.
• W2467960635 cites W2011690214 @default.
• W2467960635 cites W2013196047 @default.
• W2467960635 cites W2015175027 @default.
• W2467960635 cites W2023496907 @default.
• W2467960635 cites W2030349812 @default.
• W2467960635 cites W2035974120 @default.
• W2467960635 cites W2047992261 @default.
• W2467960635 cites W2048354832 @default.
• W2467960635 cites W2053195947 @default.
• W2467960635 cites W2063213431 @default.
• W2467960635 cites W2086040324 @default.
• W2467960635 cites W2086818383 @default.
• W2467960635 cites W2096048497 @default.
• W2467960635 cites W2096617772 @default.
• W2467960635 cites W2102298863 @default.
• W2467960635 cites W2105025714 @default.
• W2467960635 cites W2127102950 @default.
• W2467960635 cites W2139347614 @default.
• W2467960635 cites W2165901622 @default.
• W2467960635 cites W2169379435 @default.
• W2467960635 cites W2169917705 @default.
• W2467960635 doi "https://doi.org/10.1016/j.bbrc.2016.07.028" @default.
• W2467960635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27395339" @default.
• W2467960635 hasPublicationYear "2016" @default.
• W2467960635 type Work @default.
• W2467960635 sameAs 2467960635 @default.
• W2467960635 citedByCount "12" @default.
• W2467960635 countsByYear W24679606352017 @default.
• W2467960635 countsByYear W24679606352018 @default.
• W2467960635 countsByYear W24679606352020 @default.
• W2467960635 countsByYear W24679606352021 @default.
• W2467960635 countsByYear W24679606352022 @default.
• W2467960635 countsByYear W24679606352023 @default.
• W2467960635 crossrefType "journal-article" @default.
• W2467960635 hasAuthorship W2467960635A5013162352 @default.
• W2467960635 hasAuthorship W2467960635A5043801433 @default.
• W2467960635 hasAuthorship W2467960635A5050433869 @default.
• W2467960635 hasConcept C104317684 @default.
• W2467960635 hasConcept C118131993 @default.
• W2467960635 hasConcept C127561419 @default.
• W2467960635 hasConcept C173396325 @default.
• W2467960635 hasConcept C185592680 @default.
• W2467960635 hasConcept C198826908 @default.
• W2467960635 hasConcept C502942594 @default.
• W2467960635 hasConcept C54355233 @default.
• W2467960635 hasConcept C55493867 @default.
• W2467960635 hasConcept C76419328 @default.
• W2467960635 hasConcept C81885089 @default.
• W2467960635 hasConcept C86803240 @default.
• W2467960635 hasConcept C95444343 @default.
• W2467960635 hasConceptScore W2467960635C104317684 @default.
• W2467960635 hasConceptScore W2467960635C118131993 @default.
• W2467960635 hasConceptScore W2467960635C127561419 @default.
• W2467960635 hasConceptScore W2467960635C173396325 @default.
• W2467960635 hasConceptScore W2467960635C185592680 @default.
• W2467960635 hasConceptScore W2467960635C198826908 @default.
• W2467960635 hasConceptScore W2467960635C502942594 @default.
• W2467960635 hasConceptScore W2467960635C54355233 @default.
• W2467960635 hasConceptScore W2467960635C55493867 @default.
• W2467960635 hasConceptScore W2467960635C76419328 @default.
• W2467960635 hasConceptScore W2467960635C81885089 @default.
• W2467960635 hasConceptScore W2467960635C86803240 @default.
• W2467960635 hasConceptScore W2467960635C95444343 @default.
• W2467960635 hasFunder F4320321408 @default.
• W2467960635 hasFunder F4320322035 @default.
• W2467960635 hasFunder F4320322120 @default.
• W2467960635 hasIssue "4" @default.
• W2467960635 hasLocation W24679606351 @default.
• W2467960635 hasLocation W24679606352 @default.
• W2467960635 hasOpenAccess W2467960635 @default.
• W2467960635 hasPrimaryLocation W24679606351 @default.
• W2467960635 hasRelatedWork W1559117395 @default.
• W2467960635 hasRelatedWork W2150576339 @default.
• W2467960635 hasRelatedWork W2345782301 @default.
• W2467960635 hasRelatedWork W2557443381 @default.
• W2467960635 hasRelatedWork W2601756074 @default.
• W2467960635 hasRelatedWork W2603579215 @default.
• W2467960635 hasRelatedWork W2623416257 @default.
• W2467960635 hasRelatedWork W2885585788 @default.

• next