Matches in SemOpenAlex for { <https://semopenalex.org/work/W2467998767> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2467998767 abstract "Purpose:With energy repainting in lung IMPT, the dose delivered is approximate to the convolution of dose in each phase with corresponding breathing PDF. This study is to compute breathing PDF weighted 4D dose in lung IMPT treatment and compare to its initial robust plan.Methods:Six lung patients were evaluated in this study. Amsterdam shroud image were generated from pre-treatment 4D cone-beam projections. Diaphragm motion curve was extract from the shroud image and the breathing PDF was generated. Each patient was planned to 60 Gy (12GyX5). In initial plans, ITV density on average CT was overridden with its maximum value for planning, using two IMPT beams with robust optimization (5mm uncertainty in patient position and 3.5% range uncertainty). The plan was applied to all 4D CT phases. The dose in each phase was deformed to a reference phase. 4D dose is reconstructed by summing all these doses based on corresponding weighting from the PDF. Plan parameters, including maximum dose (Dmax), ITV V100, homogeneity index (HI=D2/D98), R50 (50%IDL/ITV), and the lung-GTV's V12.5 and V5 were compared between the reconstructed 4D dose to initial plans.Results:The Dmax is significantly less dose in the reconstructed 4D dose, 68.12±3.5Gy, vs. 70.1±4.3Gy in the initial plans (p=0.015). No significant difference is found for the ITV V100, HI, and R50, 92.2%±15.4% vs. 96.3%±2.5% (p=0.565), 1.033±0.016 vs. 1.038±0.017 (p=0.548), 19.2±12.1 vs. 18.1±11.6 (p=0.265), for the 4D dose and initial plans, respectively. The lung-GTV V12.5 and V5 are significantly high in the 4D dose, 13.9%±4.8% vs. 13.0%±4.6% (p=0.021) and 17.6%±5.4% vs. 16.9%±5.2% (p=0.011), respectively.Conclusion:4D dose reconstruction based on phase PDF can be used to evaluate the dose received by the patient. A robust optimization based on the phase PDF may even further improve patient care." @default.
- W2467998767 created "2016-07-22" @default.
- W2467998767 creator A5011676888 @default.
- W2467998767 creator A5030200620 @default.
- W2467998767 creator A5068845250 @default.
- W2467998767 creator A5072193229 @default.
- W2467998767 creator A5072574772 @default.
- W2467998767 creator A5075699837 @default.
- W2467998767 date "2016-06-01" @default.
- W2467998767 modified "2023-09-27" @default.
- W2467998767 title "SU-F-T-191: 4D Dose Reconstruction of Intensity Modulated Proton Therapy (IMPT) Based On Breathing Probability Density Function (PDF) From 4D Cone Beam Projection Images: A Study for Lung Treatment" @default.
- W2467998767 doi "https://doi.org/10.1118/1.4956328" @default.
- W2467998767 hasPublicationYear "2016" @default.
- W2467998767 type Work @default.
- W2467998767 sameAs 2467998767 @default.
- W2467998767 citedByCount "0" @default.
- W2467998767 crossrefType "journal-article" @default.
- W2467998767 hasAuthorship W2467998767A5011676888 @default.
- W2467998767 hasAuthorship W2467998767A5030200620 @default.
- W2467998767 hasAuthorship W2467998767A5068845250 @default.
- W2467998767 hasAuthorship W2467998767A5072193229 @default.
- W2467998767 hasAuthorship W2467998767A5072574772 @default.
- W2467998767 hasAuthorship W2467998767A5075699837 @default.
- W2467998767 hasConcept C105702510 @default.
- W2467998767 hasConcept C120665830 @default.
- W2467998767 hasConcept C121332964 @default.
- W2467998767 hasConcept C126838900 @default.
- W2467998767 hasConcept C168834538 @default.
- W2467998767 hasConcept C201645570 @default.
- W2467998767 hasConcept C2779244869 @default.
- W2467998767 hasConcept C2989005 @default.
- W2467998767 hasConcept C33923547 @default.
- W2467998767 hasConcept C39300077 @default.
- W2467998767 hasConcept C509974204 @default.
- W2467998767 hasConcept C71924100 @default.
- W2467998767 hasConcept C93038891 @default.
- W2467998767 hasConceptScore W2467998767C105702510 @default.
- W2467998767 hasConceptScore W2467998767C120665830 @default.
- W2467998767 hasConceptScore W2467998767C121332964 @default.
- W2467998767 hasConceptScore W2467998767C126838900 @default.
- W2467998767 hasConceptScore W2467998767C168834538 @default.
- W2467998767 hasConceptScore W2467998767C201645570 @default.
- W2467998767 hasConceptScore W2467998767C2779244869 @default.
- W2467998767 hasConceptScore W2467998767C2989005 @default.
- W2467998767 hasConceptScore W2467998767C33923547 @default.
- W2467998767 hasConceptScore W2467998767C39300077 @default.
- W2467998767 hasConceptScore W2467998767C509974204 @default.
- W2467998767 hasConceptScore W2467998767C71924100 @default.
- W2467998767 hasConceptScore W2467998767C93038891 @default.
- W2467998767 hasLocation W24679987671 @default.
- W2467998767 hasOpenAccess W2467998767 @default.
- W2467998767 hasPrimaryLocation W24679987671 @default.
- W2467998767 hasRelatedWork W1967555156 @default.
- W2467998767 hasRelatedWork W1982752566 @default.
- W2467998767 hasRelatedWork W1989294936 @default.
- W2467998767 hasRelatedWork W1993192413 @default.
- W2467998767 hasRelatedWork W2000706823 @default.
- W2467998767 hasRelatedWork W2003141729 @default.
- W2467998767 hasRelatedWork W2008024424 @default.
- W2467998767 hasRelatedWork W2015254307 @default.
- W2467998767 hasRelatedWork W2022859582 @default.
- W2467998767 hasRelatedWork W2025994132 @default.
- W2467998767 hasRelatedWork W2027560773 @default.
- W2467998767 hasRelatedWork W2028501849 @default.
- W2467998767 hasRelatedWork W2036017703 @default.
- W2467998767 hasRelatedWork W2057610891 @default.
- W2467998767 hasRelatedWork W2074444949 @default.
- W2467998767 hasRelatedWork W2267955793 @default.
- W2467998767 hasRelatedWork W2888177476 @default.
- W2467998767 hasRelatedWork W2946997036 @default.
- W2467998767 hasRelatedWork W3029706226 @default.
- W2467998767 hasRelatedWork W3110446794 @default.
- W2467998767 isParatext "false" @default.
- W2467998767 isRetracted "false" @default.
- W2467998767 magId "2467998767" @default.
- W2467998767 workType "article" @default.