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- W2468014779 abstract "Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs, with five subtypes named M1-M5) are a unique subclass of RGCs with axons that project directly to many brain nuclei involved in non-image-forming functions such as circadian photoentrainment and the pupillary light reflex. Recent evidence suggests that melanopsin-based signals also influence image-forming visual function, including light adaptation, but the mechanisms involved are unclear. Intriguingly, a small population of M1 ipRGCs have intraretinal axon collaterals that project toward the outer retina. Using genetic mouse models, we provide three lines of evidence showing that these axon collaterals make connections with upstream dopaminergic amacrine cells (DACs): (1) ipRGC signaling to DACs is blocked by tetrodotoxin both in vitro and in vivo, indicating that ipRGC-to-DAC transmission requires voltage-gated Na(+) channels; (2) this transmission is partly dependent on N-type Ca(2+) channels, which are possibly expressed in the axon collateral terminals of ipRGCs; and (3) fluorescence microscopy reveals that ipRGC axon collaterals make putative presynaptic contact with DACs. We further demonstrate that elimination of M1 ipRGCs attenuates light adaptation, as evidenced by an impaired electroretinogram b-wave from cones, whereas a dopamine receptor agonist can potentiate the cone-driven b-wave of retinas lacking M1 ipRGCs. Together, the results strongly suggest that ipRGCs transmit luminance signals retrogradely to the outer retina through the dopaminergic system and in turn influence retinal light adaptation.Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) comprise a third class of retinal photoreceptors that are known to mediate physiological responses such as circadian photoentrainment. However, investigation into whether and how ipRGCs contribute to vision has just begun. Here, we provide convergent anatomical and physiological evidence that axon collaterals of ipRGCs constitute a centrifugal pathway to DACs, conveying melanopsin-based signals from the innermost retina to the outer retina. We further demonstrate that retrograde signals likely influence visual processing because elimination of axon collateral-bearing ipRGCs impairs light adaptation by limiting dopamine-dependent facilitation of the cone pathway. Our findings strongly support the hypothesis that retrograde melanopsin-based signaling influences visual function locally within the retina, a notion that refutes the dogma that RGCs only provide physiological signals to the brain." @default.
- W2468014779 created "2016-07-22" @default.
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- W2468014779 date "2016-07-06" @default.
- W2468014779 modified "2023-10-15" @default.
- W2468014779 title "M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina" @default.
- W2468014779 cites W1479926654 @default.
- W2468014779 cites W1605371170 @default.
- W2468014779 cites W167088721 @default.
- W2468014779 cites W1825366906 @default.
- W2468014779 cites W1954947851 @default.
- W2468014779 cites W1967244959 @default.
- W2468014779 cites W1968786793 @default.
- W2468014779 cites W1974899081 @default.
- W2468014779 cites W1985345388 @default.
- W2468014779 cites W1988390116 @default.
- W2468014779 cites W1992420220 @default.
- W2468014779 cites W1993976719 @default.
- W2468014779 cites W1999659875 @default.
- W2468014779 cites W2001026574 @default.
- W2468014779 cites W2002761019 @default.
- W2468014779 cites W2003410687 @default.
- W2468014779 cites W2008135767 @default.
- W2468014779 cites W2009077913 @default.
- W2468014779 cites W2011770871 @default.
- W2468014779 cites W2013579519 @default.
- W2468014779 cites W2014028088 @default.
- W2468014779 cites W2021608851 @default.
- W2468014779 cites W2022197238 @default.
- W2468014779 cites W2022586338 @default.
- W2468014779 cites W2031328896 @default.
- W2468014779 cites W2031626699 @default.
- W2468014779 cites W2032255062 @default.
- W2468014779 cites W2032336503 @default.
- W2468014779 cites W2033354730 @default.
- W2468014779 cites W2035460326 @default.
- W2468014779 cites W2035853180 @default.
- W2468014779 cites W2036239753 @default.
- W2468014779 cites W2036992232 @default.
- W2468014779 cites W2042432891 @default.
- W2468014779 cites W2042849870 @default.
- W2468014779 cites W2044774559 @default.
- W2468014779 cites W2046518102 @default.
- W2468014779 cites W2051767415 @default.
- W2468014779 cites W2057012057 @default.
- W2468014779 cites W2057601872 @default.
- W2468014779 cites W2057663200 @default.
- W2468014779 cites W2061683639 @default.
- W2468014779 cites W2063344882 @default.
- W2468014779 cites W2065416066 @default.
- W2468014779 cites W2066482151 @default.
- W2468014779 cites W2070892103 @default.
- W2468014779 cites W2072060769 @default.
- W2468014779 cites W2072759014 @default.
- W2468014779 cites W2076640004 @default.
- W2468014779 cites W2080411562 @default.
- W2468014779 cites W2081454494 @default.
- W2468014779 cites W2081957674 @default.
- W2468014779 cites W2082823588 @default.
- W2468014779 cites W2084081857 @default.
- W2468014779 cites W2085302681 @default.
- W2468014779 cites W2088214898 @default.
- W2468014779 cites W2095827801 @default.
- W2468014779 cites W2096517177 @default.
- W2468014779 cites W2099370772 @default.
- W2468014779 cites W2105050095 @default.
- W2468014779 cites W2110382306 @default.
- W2468014779 cites W2111530177 @default.
- W2468014779 cites W2114400482 @default.
- W2468014779 cites W2116156647 @default.
- W2468014779 cites W2119719550 @default.
- W2468014779 cites W2121082491 @default.
- W2468014779 cites W2128754473 @default.
- W2468014779 cites W2143925739 @default.
- W2468014779 cites W2144625840 @default.
- W2468014779 cites W2149729365 @default.
- W2468014779 cites W2149770379 @default.
- W2468014779 cites W2162754608 @default.
- W2468014779 cites W2165085959 @default.
- W2468014779 cites W2166273532 @default.
- W2468014779 cites W838876216 @default.
- W2468014779 doi "https://doi.org/10.1523/jneurosci.3500-15.2016" @default.
- W2468014779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4938862" @default.
- W2468014779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27383593" @default.
- W2468014779 hasPublicationYear "2016" @default.
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