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• W2468038785 abstract "Background: Globally, acute respiratory infection (ARI) and urinary tract infection (UTI) are the predominant infectious triggers of relapse in idiopathic nephrotic syndrome. In the West African sub-region, most studies on the syndrome have focused essentially on the clinical features, steroid sensitivity and histology patterns. Aim: The present study aims to determine the triggers and patterns of relapse in Nigerian pediatric patients with idiopathic nephrotic syndrome. Subjects and Methods: A retrospective analysis of the case notes of 30 patients with idiopathic nephrotic syndrome was conducted using a structured proforma. Data were analysed with the Statistical Package for Social Sciences (SPSS) version 17.0. Variables were expressed in frequencies and proportions (percentages). Chi-square test and Spearman's rank correlation coefficient for non-parametric analysis were applied as appropriate, and p value of less than 0.05 was adopted as the level of statistical significance. Results: The most common identified trigger of relapse was UTI, which was recorded in 12/30 (40.0%) of the patients. ARI and malaria infection ranked second on the list of trigger factors: each documented in 7/30 (23.3%) of the patients. Non-compliance to drugs was noted in 1/30 (3.3%) while no trigger factor was identified in 3/30 (10.1%) of the patients. On the whole, infrequent relapses were seen in 16/30 (53.4%) of the patients, frequent relapses in 10/30 (33.3%), while 4/30 (13.3%) had no recorded relapses. The patterns were not significantly influenced by the patients' age (p=0.479), and socio- economic class (p=0.918), and the type of initial treatment regimen (p=0.829). Conclusions: Frequent relapses still remain a challenge in the management of nephrotic syndrome. Infectious triggers constitute a major cause of relapse; and malaria may be an unrecognized trigger in the tropics. Relapse-specific interventions may have to be expanded to include malaria chemoprophylaxis such as intermittent preventive therapy, particularly for nephrotic patients in the tropics where malaria appears endemic." @default.
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• W2468038785 date "2016-01-01" @default.
• W2468038785 modified "2023-09-26" @default.
• W2468038785 title "The Triggers and Patterns of Relapse in Childhood Idiopathic Nephrotic Syndrome: A Retrospective, Descriptive Study in a Tertiary Hospital, South- East Nigeria" @default.
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