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- W2468052181 abstract "It is now widely accepted that the angiotensin AT2 receptor (AT2R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT2R agonist C21 accelerated our understanding of AT2R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond." @default.
- W2468052181 created "2016-07-22" @default.
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- W2468052181 date "2012-07-27" @default.
- W2468052181 modified "2023-10-03" @default.
- W2468052181 title "Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond" @default.
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- W2468052181 doi "https://doi.org/10.1007/s11906-012-0291-6" @default.
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