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- W2468097957 abstract "We developed two botanical formulations named, PG201 (drug) and Eucomix (nutraceuticals). These formulations have previously been shown to contain strong anti-inflammatory and analgesic effects in animal models, and in double-blind placebo controlled Phase II and Phase III clinical trials in the case of PG201. We found that therapeutic activities of these formulations result in part from activation of HO-1. Nrf2 is well-known to play a critical role(s) in anti-oxidative and cytoprotective processes through the induction of a variety of anti-oxidative and Phase II detoxification enzymes, including HO-1. When effects of PG201 on Nrf2 were tested in in vitro culture systems, treatment with this botanical formulation increased both the total amount of Nrf2 protein and also its nuclear level through the increase of dissociation of Nrf2 from Keap1, whereas PG201-mediated activation of HO-1 expression was almost completely blocked in bone-marrow derived macrophages (BMDMs) prepared from Nrf2 deficient mice. Taken together, our botanical formulations may be used not only to treat arthritic symptoms but also maintain joint health to prevent related diseases. (NOTE: PG201 is an ETC drug recently approved by Korea’s FDA, and Eucomix is a functional food currently available from the market in Korea.)" @default.
- W2468097957 created "2016-07-22" @default.
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- W2468097957 date "2016-04-08" @default.
- W2468097957 modified "2023-09-24" @default.
- W2468097957 title "Therapeutic effects of anti-arthritic botanical formulations, PG201 and Eucomix, in arthritis animal models and humans with osteoarthritis." @default.
- W2468097957 doi "https://doi.org/10.18143/jisanh_v3i1_925" @default.
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