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- W2468154128 endingPage "929" @default.
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- W2468154128 abstract "Lymphopenia is strongly associated with autoimmune diseases. The molecular mechanisms that link both phenomena are still unclear, but certain key pathways have been described. Central tolerance is as important as peripheral. In the earlier, epithelial and dendritic cells play a crucial role in the selection of clones. In the latter, regulatory T cells (Tregs) rise as inductors of anergy in order to prevent the development of autoimmune pathology. In lymphopenic conditions, T cells develop the process of lymphopenia-induced proliferation (LIP). A complex interaction between the major histocompatibility complex (MHC) and the T cell receptor (TCR) makes this process possible. Furthermore, IL-7 can act synergistically or in an independent manner to promote LIP. A lack of Transforming Growth Factor-β (TGF-β) was recently described as the second hit needed to develop autoimmunity in a lymphopenic microenvironment, given its actions in Tregs and its interaction with CTLA-4. Regarding autoimmune clinical scenarios, lymphopenia is related to both, systemic and organ-specific diseases. Thus, the molecular study of such patients has been limited and needs to be widened to the pathways shown here to be involved in the development of lymphopenia and autoimmunity." @default.
- W2468154128 created "2016-07-22" @default.
- W2468154128 creator A5014995059 @default.
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- W2468154128 creator A5027323597 @default.
- W2468154128 creator A5071061072 @default.
- W2468154128 creator A5082235231 @default.
- W2468154128 date "2016-10-01" @default.
- W2468154128 modified "2023-10-18" @default.
- W2468154128 title "Lymphopenia and autoimmunity: A double-edged sword" @default.
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