Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468214419> ?p ?o ?g. }
- W2468214419 endingPage "10" @default.
- W2468214419 startingPage "1" @default.
- W2468214419 abstract "Background . 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims . To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-induced colitis. Materials and Methods . C57BL/6J (B6) mice were treated with either low-dose (1.0 mg/kg) or high-dose (2.0 mg/kg) 5-HT by enema, low-dose (1.0%) or high-dose (2.5%) DSS, or combined low-dose (1.0%) DSS and (1.0 mg/kg) 5-HT. Mouse colitis was analyzed. MMPs and tissue inhibitors of MMPs (TIMPs) mRNA were measured by real-time quantitative RT-PCR in mouse colon and in human Caco-2 cells and neutrophils. MMP-3 and MMP-9 protein levels were quantified from immunohistochemistry (IHC) images of mouse colons. Results . 5-HT exacerbated DSS-induced colitis, low-dose 5-HT induces both MMP-3 and MMP-9, and high-dose 5-HT only increased MMP-3 mRNA expression in mouse colon. Mouse colon MMP-3 and MMP-9 protein levels were also elevated by 5-HT treatment. The MMP-2, TIMP-1, and TIMP-2 mRNA levels were increased in the inflamed colon. 5-HT induced MMP-3 and MMP-9 mRNA expression in Caco-2 and human neutrophils, respectively, in vitro. Conclusion . 5-HT induced MMP-3 and MMP-9 expression in mouse colon; these elevated MMPs may contribute to DSS-induced colitis." @default.
- W2468214419 created "2016-07-22" @default.
- W2468214419 creator A5019568188 @default.
- W2468214419 creator A5026389808 @default.
- W2468214419 creator A5027228264 @default.
- W2468214419 creator A5031870274 @default.
- W2468214419 creator A5063331443 @default.
- W2468214419 creator A5067137163 @default.
- W2468214419 creator A5072814315 @default.
- W2468214419 creator A5072815126 @default.
- W2468214419 creator A5073898745 @default.
- W2468214419 date "2016-01-01" @default.
- W2468214419 modified "2023-10-12" @default.
- W2468214419 title "Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon" @default.
- W2468214419 cites W136766227 @default.
- W2468214419 cites W1499784197 @default.
- W2468214419 cites W1526493787 @default.
- W2468214419 cites W1564674105 @default.
- W2468214419 cites W1581404300 @default.
- W2468214419 cites W1596258860 @default.
- W2468214419 cites W1907864108 @default.
- W2468214419 cites W1911382233 @default.
- W2468214419 cites W1950165330 @default.
- W2468214419 cites W1951491012 @default.
- W2468214419 cites W1969426171 @default.
- W2468214419 cites W1970178265 @default.
- W2468214419 cites W1973806241 @default.
- W2468214419 cites W1980368321 @default.
- W2468214419 cites W1986079650 @default.
- W2468214419 cites W1986406665 @default.
- W2468214419 cites W1995857710 @default.
- W2468214419 cites W2003135973 @default.
- W2468214419 cites W2004399138 @default.
- W2468214419 cites W2010391271 @default.
- W2468214419 cites W2012162957 @default.
- W2468214419 cites W2013381549 @default.
- W2468214419 cites W2014001501 @default.
- W2468214419 cites W2026576624 @default.
- W2468214419 cites W2027303902 @default.
- W2468214419 cites W2035084522 @default.
- W2468214419 cites W2035663126 @default.
- W2468214419 cites W2037786647 @default.
- W2468214419 cites W2038479423 @default.
- W2468214419 cites W2042368853 @default.
- W2468214419 cites W2049270310 @default.
- W2468214419 cites W2051692635 @default.
- W2468214419 cites W2055295898 @default.
- W2468214419 cites W2056142149 @default.
- W2468214419 cites W2057059946 @default.
- W2468214419 cites W2072907428 @default.
- W2468214419 cites W2075583206 @default.
- W2468214419 cites W2077470579 @default.
- W2468214419 cites W2078722963 @default.
- W2468214419 cites W2081575079 @default.
- W2468214419 cites W2082083375 @default.
- W2468214419 cites W2085139899 @default.
- W2468214419 cites W2085852125 @default.
- W2468214419 cites W2086683881 @default.
- W2468214419 cites W2089285664 @default.
- W2468214419 cites W2091080587 @default.
- W2468214419 cites W2097566770 @default.
- W2468214419 cites W2097785181 @default.
- W2468214419 cites W2107237727 @default.
- W2468214419 cites W2113309273 @default.
- W2468214419 cites W2127568565 @default.
- W2468214419 cites W2132084988 @default.
- W2468214419 cites W2138406651 @default.
- W2468214419 cites W2139666900 @default.
- W2468214419 cites W2154401382 @default.
- W2468214419 cites W2155602568 @default.
- W2468214419 cites W2162098634 @default.
- W2468214419 cites W2166912481 @default.
- W2468214419 cites W2213551981 @default.
- W2468214419 cites W2322634064 @default.
- W2468214419 cites W2419905396 @default.
- W2468214419 cites W4211241312 @default.
- W2468214419 cites W4250908540 @default.
- W2468214419 doi "https://doi.org/10.1155/2016/5359768" @default.
- W2468214419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4949340" @default.
- W2468214419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27478308" @default.
- W2468214419 hasPublicationYear "2016" @default.
- W2468214419 type Work @default.
- W2468214419 sameAs 2468214419 @default.
- W2468214419 citedByCount "14" @default.
- W2468214419 countsByYear W24682144192016 @default.
- W2468214419 countsByYear W24682144192017 @default.
- W2468214419 countsByYear W24682144192018 @default.
- W2468214419 countsByYear W24682144192020 @default.
- W2468214419 countsByYear W24682144192021 @default.
- W2468214419 countsByYear W24682144192022 @default.
- W2468214419 countsByYear W24682144192023 @default.
- W2468214419 crossrefType "journal-article" @default.
- W2468214419 hasAuthorship W2468214419A5019568188 @default.
- W2468214419 hasAuthorship W2468214419A5026389808 @default.
- W2468214419 hasAuthorship W2468214419A5027228264 @default.
- W2468214419 hasAuthorship W2468214419A5031870274 @default.
- W2468214419 hasAuthorship W2468214419A5063331443 @default.
- W2468214419 hasAuthorship W2468214419A5067137163 @default.