Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468300047> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2468300047 endingPage "304" @default.
- W2468300047 startingPage "299" @default.
- W2468300047 abstract "Twenty-four patients with effort angina and positive exercise stress test performed four control exercise stress tests, two tests while taking propranolol (240 mg/day) and two tests while taking verapamil (320 mg/day), in a randomized crossover sequence. For each test the following parameters were measured: time and rate-pressure product at ischemia; intercept and slope of the linear regression between rate-pressure product and minutes of exercise. Group analysis showed that both drugs improved time to ischemia significantly and to the same extent. However, eight patients responded preferentially to verapamil in contrast to 12 patients on propranolol. The remaining four patients responded equally to both drugs. In verapamil responders, verapamil increased time to ischemia by decreasing intercept and increasing rate-pressure product at ischemia. In these patients, propranolol did not increase time to ischemia because of a marked decrease in rate-pressure product at ischemia. In propranolol responders the significant increase in time to ischemia during propranolol was the result of a decrease in intercept and slope. The ineffectiveness of verapamil in these patients was related to a slight decrease in intercept without any increase in rate-pressure product at ischemia. The preferential response to one of the two drugs could not be predicted on the basis of clinical and angiographic features. In conclusion, in patients with effort angina, medical treatment should be personalized and based on a direct and objective verification of a drug's efficacy since different mechanisms can modulate exercise tolerance." @default.
- W2468300047 created "2016-07-22" @default.
- W2468300047 creator A5002166478 @default.
- W2468300047 creator A5010730180 @default.
- W2468300047 creator A5015371638 @default.
- W2468300047 creator A5022717878 @default.
- W2468300047 creator A5050680479 @default.
- W2468300047 date "1989-09-01" @default.
- W2468300047 modified "2023-10-18" @default.
- W2468300047 title "Elective response to propranolol or verapamil in ischemia on effort." @default.
- W2468300047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2676121" @default.
- W2468300047 hasPublicationYear "1989" @default.
- W2468300047 type Work @default.
- W2468300047 sameAs 2468300047 @default.
- W2468300047 citedByCount "4" @default.
- W2468300047 crossrefType "journal-article" @default.
- W2468300047 hasAuthorship W2468300047A5002166478 @default.
- W2468300047 hasAuthorship W2468300047A5010730180 @default.
- W2468300047 hasAuthorship W2468300047A5015371638 @default.
- W2468300047 hasAuthorship W2468300047A5022717878 @default.
- W2468300047 hasAuthorship W2468300047A5050680479 @default.
- W2468300047 hasConcept C126322002 @default.
- W2468300047 hasConcept C142724271 @default.
- W2468300047 hasConcept C164705383 @default.
- W2468300047 hasConcept C204787440 @default.
- W2468300047 hasConcept C27081682 @default.
- W2468300047 hasConcept C2777022698 @default.
- W2468300047 hasConcept C2777953023 @default.
- W2468300047 hasConcept C2778151854 @default.
- W2468300047 hasConcept C2778425758 @default.
- W2468300047 hasConcept C42219234 @default.
- W2468300047 hasConcept C500558357 @default.
- W2468300047 hasConcept C519063684 @default.
- W2468300047 hasConcept C541997718 @default.
- W2468300047 hasConcept C71316499 @default.
- W2468300047 hasConcept C71924100 @default.
- W2468300047 hasConcept C84393581 @default.
- W2468300047 hasConcept C87813604 @default.
- W2468300047 hasConceptScore W2468300047C126322002 @default.
- W2468300047 hasConceptScore W2468300047C142724271 @default.
- W2468300047 hasConceptScore W2468300047C164705383 @default.
- W2468300047 hasConceptScore W2468300047C204787440 @default.
- W2468300047 hasConceptScore W2468300047C27081682 @default.
- W2468300047 hasConceptScore W2468300047C2777022698 @default.
- W2468300047 hasConceptScore W2468300047C2777953023 @default.
- W2468300047 hasConceptScore W2468300047C2778151854 @default.
- W2468300047 hasConceptScore W2468300047C2778425758 @default.
- W2468300047 hasConceptScore W2468300047C42219234 @default.
- W2468300047 hasConceptScore W2468300047C500558357 @default.
- W2468300047 hasConceptScore W2468300047C519063684 @default.
- W2468300047 hasConceptScore W2468300047C541997718 @default.
- W2468300047 hasConceptScore W2468300047C71316499 @default.
- W2468300047 hasConceptScore W2468300047C71924100 @default.
- W2468300047 hasConceptScore W2468300047C84393581 @default.
- W2468300047 hasConceptScore W2468300047C87813604 @default.
- W2468300047 hasIssue "6" @default.
- W2468300047 hasLocation W24683000471 @default.
- W2468300047 hasOpenAccess W2468300047 @default.
- W2468300047 hasPrimaryLocation W24683000471 @default.
- W2468300047 hasRelatedWork W1576815836 @default.
- W2468300047 hasRelatedWork W1991554215 @default.
- W2468300047 hasRelatedWork W2005230358 @default.
- W2468300047 hasRelatedWork W2022397683 @default.
- W2468300047 hasRelatedWork W2068852473 @default.
- W2468300047 hasRelatedWork W2087850346 @default.
- W2468300047 hasRelatedWork W2128123350 @default.
- W2468300047 hasRelatedWork W2416999139 @default.
- W2468300047 hasRelatedWork W2431166994 @default.
- W2468300047 hasRelatedWork W2468300047 @default.
- W2468300047 hasVolume "5" @default.
- W2468300047 isParatext "false" @default.
- W2468300047 isRetracted "false" @default.
- W2468300047 magId "2468300047" @default.
- W2468300047 workType "article" @default.