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- W2468331498 abstract "To construct DNA and recombinant adenovirus vector vaccines containing an env gene from the prevalent subtype B strain in China and try to use them for therapeutic and prophylactic vaccines.The candidate plasmid DNA vaccine pVR-gp160 and recombinant adenovirus vaccine rAdV-gp160 were constructed separately. BALB/c mice were immunized with these two vaccines in different administration schemes. HIV-1 Gp120-specific cellular responses and antibody levels were detected by ELISPOT and ELISA respectively.DNA vaccine alone and combined vaccines in a DNA prime/rAdV-gp160 boost vaccination regimen induced high level of Gp120-specific cellular responses. While low level of Gp120-specific antibodies were elicited in all groups.DNA and rAdV vaccines could efficiently express Gp160 protein and activate specific cellular responses." @default.
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- W2468331498 date "2010-12-01" @default.
- W2468331498 modified "2023-09-27" @default.
- W2468331498 title "[Immunogenicity of plasmid DNA and adenoviral vectors encoding HIV-1 subtype B env gene]." @default.
- W2468331498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21604562" @default.
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