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- W2468376721 abstract "Circulating bone marrow (BM)-derived stem and progenitorcells (SPCs) participate in turnover of vascular endotheliumand myocardial repair after acute coronary syndromes. Acutemyocardial infarction (MI) produces a generalized inflammatoryreaction, including mobilization of SPCs, increased localproduction of chemoattractants in the ischemic myocardium,as well as neural and humoral signalsactivating the SPC egressfrom the BM. Several types of circulating BM cells wereidentified in the peripheral blood, including hematopoietic stemcells, endothelial progenitor cells, mesenchymal stromal cells,circulating angiogenic cells and pluripotent very small embryo-nic-like cells; however, the contribution of circulating cells tothe myocardial and endothelial repair is still unknown. Thenumber and function of these cells is impaired in patients withdiabetes and other cardiovascular risk factors, but can beimproved by physical exercise and use of statins. Themobilization of SPCs in acute coronary syndromes and stablecoronary artery disease seems to predict the clinical outcomesin selected groups of patients. Interpretation of the findings hasto incorporate other factors that modulate the process ofmobilization, such as coexisting diseases, age and medica-tions. This review discusses the mobilization of SPCs in acuteischemia (MI, stroke), as well as in stable cardiovasculardisease, and highlights the possibility of using the SPC as amarker of cardiovascular risk.Leukemia (2012) 26, 23–33; doi:10.1038/leu.2011.184;published online 26 July 2011Keywords: mobilization; stem cells; endothelial progenitor cells;very small embryonic-like cells; myocardial infarction" @default.
- W2468376721 created "2016-07-22" @default.
- W2468376721 creator A5015578089 @default.
- W2468376721 creator A5045987075 @default.
- W2468376721 creator A5073792258 @default.
- W2468376721 creator A5080753934 @default.
- W2468376721 creator A5088144455 @default.
- W2468376721 date "2012-01-01" @default.
- W2468376721 modified "2023-09-23" @default.
- W2468376721 title "SPOTLIGHT REVIEW Mobilization of stem and progenitor cells in cardiovascular diseases" @default.
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