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• W2468388673 abstract "While cervical cancer continues to decrease, anal cancer incidence is on the rise with an estimated 8,080 new cases in the United States in 2016 and a 14% mortality rate. In the past few decades, African American men have had the sharpest increase in incidence rates of anal cancer, as well as a shorter survival rate. Besides early detection of cervical cancer using pap smear, vaccines have also played a role in decrease of cervical cancer incidence. FDA recently approved a 9-valent vaccine which has the potential to increase prevention of ano-genital cancers from 70% to 90%, but no research study has investigated whether the HPV types in 9-valent will target the HPV types which are most commonly associated in anal SCC with the African American (AA) cohort. In this pilot study, we analyzed the HPV genotype distribution in 24-HPV positive-anal lesions from the AA population using type-specific PCR. Overall, 17 different HPV types were detected where only HPV-16 and not 18 associated with anal SCC. HPV types 35 and 59 were associated with AIN2-3. Based on our study, it can be speculated that distribution of HPV genotypes may vary by race/ethnicity. In general, it is our opinion that the new 9-valent vaccine might have limited value given that different races/ethnicities might have different genotypic distribution. For further validation, we suggest future investigations and clinical trials with inclusion of minority populations. ." @default.
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• W2468388673 date "2016-06-15" @default.
• W2468388673 modified "2023-09-27" @default.
• W2468388673 title "HPVs detected in African Americans Not Represented in Vaccines" @default.
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• W2468388673 doi "https://doi.org/10.15406/jcpcr.2016.05.00152" @default.
• W2468388673 hasPublicationYear "2016" @default.
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