FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468390511> ?p ?o ?g. }

• W2468390511 abstract "BACKGROUND & AIMS: With the limited efficacy of current therapy for chronic hepatitis C, modifiable risk factors for liver disease progression are important to identify. Because obesity is associated with liver disease, we examined the effects of weight-related conditions on disease outcomes in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) trial. METHODS: Of 1050 patients, 985 could be evaluated for predefined progression of liver disease not related to hepatocellular carcinoma. Clinical outcomes were determined over 3.5 years for all patients and progression to cirrhosis on protocol biopsy among patients who had bridging fibrosis (56.5% of cohort) at entry. RESULTS: At study entry, median body mass index was high (29.2 kg/m 2 ) and accompanied by other weight-related conditions, including diabetes (24.9%), high median waist circumference, and insulin resistance (by updated homeostasis model assessment of insulin resistance; HOMA2-IR). Among noninvasive measures, HOMA2-IR was most strongly associated with outcomes with hazard ratio (HR) of 1.26 per quartile increase (95% CI, 1.09‐1.45). Presence of steatosis on baseline biopsy was associated with an increased outcome rate among patients with bridging fibrosis (P .0001) and a decreased rate among patients with cirrhosis (P .006). Presence of Mallory bodies was associated with outcomes (HR, 1.59; 95% CI, 1.10‐2.31) as was significant weight change of 5% in the first year after randomization (HR, 1.25 per category increase in weight, 95% CI, 1.01‐1.55). CONCLUSIONS: Insulin resistance, histologic features of fatty liver disease, and weight change were associated with outcomes of chronic hepatitis C. Improvement in these weight-related factors might modify disease progression." @default.
• W2468390511 created "2016-07-22" @default.
• W2468390511 creator A5013138122 @default.
• W2468390511 creator A5018098715 @default.
• W2468390511 creator A5020069661 @default.
• W2468390511 creator A5043162110 @default.
• W2468390511 creator A5055401131 @default.
• W2468390511 creator A5066255279 @default.
• W2468390511 creator A5077140895 @default.
• W2468390511 creator A5077980742 @default.
• W2468390511 date "2009-01-01" @default.
• W2468390511 modified "2023-09-27" @default.
• W2468390511 title "CLINICAL—LIVER, PANCREAS, AND BILIARY TRACT Weight-Related Effects on Disease Progression in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial" @default.
• W2468390511 cites W1981900811 @default.
• W2468390511 cites W1997076034 @default.
• W2468390511 cites W2005135255 @default.
• W2468390511 cites W2016409892 @default.
• W2468390511 cites W2028301661 @default.
• W2468390511 cites W2037251110 @default.
• W2468390511 cites W2039070191 @default.
• W2468390511 cites W2040668343 @default.
• W2468390511 cites W2047257800 @default.
• W2468390511 cites W2054221614 @default.
• W2468390511 cites W2057349878 @default.
• W2468390511 cites W2070486530 @default.
• W2468390511 cites W2090439540 @default.
• W2468390511 cites W2096613362 @default.
• W2468390511 cites W2097094525 @default.
• W2468390511 cites W2113363440 @default.
• W2468390511 cites W2115951150 @default.
• W2468390511 cites W2124620553 @default.
• W2468390511 cites W2127807241 @default.
• W2468390511 cites W2144852094 @default.
• W2468390511 cites W2145975149 @default.
• W2468390511 cites W2168448201 @default.
• W2468390511 cites W2169151999 @default.
• W2468390511 hasPublicationYear "2009" @default.
• W2468390511 type Work @default.
• W2468390511 sameAs 2468390511 @default.
• W2468390511 citedByCount "0" @default.
• W2468390511 crossrefType "journal-article" @default.
• W2468390511 hasAuthorship W2468390511A5013138122 @default.
• W2468390511 hasAuthorship W2468390511A5018098715 @default.
• W2468390511 hasAuthorship W2468390511A5020069661 @default.
• W2468390511 hasAuthorship W2468390511A5043162110 @default.
• W2468390511 hasAuthorship W2468390511A5055401131 @default.
• W2468390511 hasAuthorship W2468390511A5066255279 @default.
• W2468390511 hasAuthorship W2468390511A5077140895 @default.
• W2468390511 hasAuthorship W2468390511A5077980742 @default.
• W2468390511 hasConcept C126322002 @default.
• W2468390511 hasConcept C2775934546 @default.
• W2468390511 hasConcept C2776175330 @default.
• W2468390511 hasConcept C2776455275 @default.
• W2468390511 hasConcept C2776954865 @default.
• W2468390511 hasConcept C2777075537 @default.
• W2468390511 hasConcept C2777214474 @default.
• W2468390511 hasConcept C2777391703 @default.
• W2468390511 hasConcept C2777766500 @default.
• W2468390511 hasConcept C2778019345 @default.
• W2468390511 hasConcept C2778772119 @default.
• W2468390511 hasConcept C2779134260 @default.
• W2468390511 hasConcept C2779306644 @default.
• W2468390511 hasConcept C3017894415 @default.
• W2468390511 hasConcept C511355011 @default.
• W2468390511 hasConcept C544821477 @default.
• W2468390511 hasConcept C71924100 @default.
• W2468390511 hasConcept C90924648 @default.
• W2468390511 hasConceptScore W2468390511C126322002 @default.
• W2468390511 hasConceptScore W2468390511C2775934546 @default.
• W2468390511 hasConceptScore W2468390511C2776175330 @default.
• W2468390511 hasConceptScore W2468390511C2776455275 @default.
• W2468390511 hasConceptScore W2468390511C2776954865 @default.
• W2468390511 hasConceptScore W2468390511C2777075537 @default.
• W2468390511 hasConceptScore W2468390511C2777214474 @default.
• W2468390511 hasConceptScore W2468390511C2777391703 @default.
• W2468390511 hasConceptScore W2468390511C2777766500 @default.
• W2468390511 hasConceptScore W2468390511C2778019345 @default.
• W2468390511 hasConceptScore W2468390511C2778772119 @default.
• W2468390511 hasConceptScore W2468390511C2779134260 @default.
• W2468390511 hasConceptScore W2468390511C2779306644 @default.
• W2468390511 hasConceptScore W2468390511C3017894415 @default.
• W2468390511 hasConceptScore W2468390511C511355011 @default.
• W2468390511 hasConceptScore W2468390511C544821477 @default.
• W2468390511 hasConceptScore W2468390511C71924100 @default.
• W2468390511 hasConceptScore W2468390511C90924648 @default.
• W2468390511 hasLocation W24683905111 @default.
• W2468390511 hasOpenAccess W2468390511 @default.
• W2468390511 hasPrimaryLocation W24683905111 @default.
• W2468390511 hasRelatedWork W189239331 @default.
• W2468390511 hasRelatedWork W2017670453 @default.
• W2468390511 hasRelatedWork W2085428347 @default.
• W2468390511 hasRelatedWork W2097680665 @default.
• W2468390511 hasRelatedWork W2118035605 @default.
• W2468390511 hasRelatedWork W2155883829 @default.
• W2468390511 hasRelatedWork W2218877772 @default.
• W2468390511 hasRelatedWork W2240818727 @default.
• W2468390511 hasRelatedWork W2536609598 @default.
• W2468390511 hasRelatedWork W2563913957 @default.
• W2468390511 hasRelatedWork W2759607062 @default.
• W2468390511 hasRelatedWork W2803058386 @default.

• next